ArticleJournal of neurophysiology2021
Loneliness is linked to specific subregional alterations in hippocampus-default network covariation.
Article in Journal of neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Lonelier people feel less empathic despite intact neural empathy responses after meditation training.Social cognitive and affective neuroscience · 2026Trial
- Lonely individuals have a more negative perception of their bodies: The mediating role of self-cognition and social perception brain network connectivity.Cognitive, affective & behavioral neuroscience · 2026Article
- Association between loneliness and hippocampal responses to dynamic social stimuli in psychotic disorders.Psychological medicine · 2025Article
- Hormonal and Behavioral Consequences of Social Isolation and Loneliness: Neuroendocrine Mechanisms and Clinical Implications.International journal of molecular sciences · 2025Review
- Loneliness in schizophrenia: Just loneliness.Annals of the New York Academy of Sciences · 2025Review
- Multimodal population study reveals the neurobiological underpinnings of chronotype.Nature human behaviour · 2025Article
- Why friendship and loneliness affect our health.Annals of the New York Academy of Sciences · 2025Review
- Longitudinal microstructural changes in 18 amygdala nuclei resonate with cortical circuits and phenomics.Communications biology · 2024Article
- Social Isolation, Brain Food Cue Processing, Eating Behaviors, and Mental Health Symptoms.JAMA network open · 2024Article
- Contributions of loneliness to cognitive impairment and dementia in older adults are independent of other risk factors and Alzheimer's pathology: a narrative review.Frontiers in human neuroscience · 2024Review
- Social Withdrawal, Loneliness, and Health in Schizophrenia: Psychological and Neural Mechanisms.Schizophrenia bulletin · 2023Article
- APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer's disease and related dementia.PLoS biology · 2022Article
- Social isolation and the brain in the pandemic era.Nature human behaviour · 2022Review
- Affective Neuroscience of Loneliness: Potential Mechanisms underlying the Association between Perceived Social Isolation, Health, and Well-Being.Journal of psychiatry and brain science · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Social interaction complexity makes humans unique. But in times of social deprivation, this strength risks exposure of important vulnerabilities. Human social neuroscience studies have placed a premium on the default network (DN). In contrast, hippocampus (HC) subfields have been intensely studied in rodents and monkeys. To bridge these two literatures, we here quantified how DN subregions systematically covary with specific HC subfields in the context of subjective social isolation (i.e., loneliness). By codecomposition using structural brain scans of ∼40,000 UK Biobank participants, loneliness was specially linked to midline subregions in the uncovered DN patterns. These association cortex patterns coincided with concomitant HC patterns implicating especially CA1 and molecular layer. These patterns also showed a strong affiliation with the fornix white matter tract and the nucleus accumbens. In addition, separable signatures of structural HC-DN covariation had distinct associations with the genetic predisposition for loneliness at the population level.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.