ArticleEnvironmental health perspectives2021
Prenatal Exposure to Nonpersistent Chemical Mixtures and Fetal Growth: A Population-Based Study.
Article in Environmental health perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- An Evaluation of Food and Nutrient Intake among Pregnant Women in The Netherlands: A Systematic Review.Nutrients · 2023Pooled it
- Relationship of prenatal pesticide exposures with prenatal ultrasound and birth growth measures among offspring of women living with HIV.International journal of hygiene and environmental health · 2026Article
- Chemical mixtures and birth weight: comparison of multipollutant models in the Maternal-Infant Research on Environmental Chemicals (MIREC) study.Environmental health : a global access science source · 2026Article
- Association of umbilical cord blood phthalate levels with neonatal growth parameters in term pregnancies.BMC pediatrics · 2026Article
- Prenatal Exposure to Mixtures of Nonpersistent Endocrine-Disrupting Chemicals and Angiogenic Biomarkers, Placental Function, and Fetal Growth.Environmental science & technology · 2026Article
- Prenatal exposure to a mixture of per- and polyfluoroalkyl substances (PFAS) and lung function and immune-related outcomes among males in childhood and young adulthood.Environmental research · 2025Article
- Fine Particulate Matter, Its Constituents, and Spontaneous Preterm Birth.JAMA network open · 2024Article
- Independent and joint effects of neighborhood-level environmental and socioeconomic exposures on body mass index in early childhood: The environmental influences on child health outcomes (ECHO) cohort.Environmental research · 2024Article
- Pesticide exposure, birth size, and gestational age in the ISA birth cohort, Costa Rica.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Prenatal exposures to phthalates and bisphenols in relation to oxidative stress: single pollutant and mixtures analyses.Environmental science and pollution research international · 2024Article
- Prenatal exposures to phthalates and life events stressors in relation to child behavior at age 4-6: A combined cohort analysis.Environment international · 2024Article
- Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells.Epigenetics communications · 2024Article
- Exposure profiles in pregnant women from a birth cohort in a highly contaminated area of southern Italy.Scientific reports · 2023Article
- Article
- Early pregnancy phthalates and replacements in relation to fetal growth: The human placenta and phthalates study.Environmental research · 2023Article
- Maternal exposure to ambient air pollution mixture and premature rupture of membranes: Evidence from a large cohort in Southern California (2008-2018).Environment international · 2023Article
- Use of personal care products during pregnancy and birth outcomes - A pilot study.Environmental research · 2023Article
- Maternal urinary bisphenols and phthalates in relation to estimated fetal weight across mid to late pregnancy.Environment international · 2023Article
- Association of ultraprocessed foods consumption and cognitive function among children aged 4-7 years: a cross-sectional data analysis.Frontiers in nutrition · 2023Article
- Urinary phthalate metabolite mixtures in pregnancy and fetal growth: Findings from the infant development and the environment study.Environment international · 2022Article
Corrections and comments
- Commented on by
Authors and funding
13 authors at 9 institutions in 4 countries.
Funding
Abstract
backgroundPrenatal exposure to mixtures of nonpersistent chemicals is universal. Most studies examining these chemicals in association with fetal growth have been restricted to single exposure models, ignoring their potentially cumulative impact.
objectiveWe aimed to assess the association between prenatal exposure to a mixture of phthalates, bisphenols, and organophosphate (OP) pesticides and fetal measures of head circumference, femur length, and weight.
methodsWithin the Generation R Study, a population-based cohort in Netherlands (
resultsThe average EFW at 18-25 wk and DISCUSSION: Higher exposure to a mixture of phthalates, bisphenols, and OP pesticides was associated with lower EFW in the midpregnancy period. In late pregnancy, these differences were similar but less pronounced. At birth, the only associations observed appeared when comparing individuals from Q1 and Q4. This finding suggests that even low levels of exposure may be sufficient to influence growth in early pregnancy, whereas higher levels may be necessary to affect birth weight. Joint exposure to nonpersistent chemicals may adversely impact fetal growth, and because these exposures are widespread, this impact could be substantial. https://doi.org/10.1289/EHP9178.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.