Evidence map›Paper›PMID 34817197›Full record

ArticleJournal of virology2022

The N-Terminal Region of Middle East Respiratory Syndrome Coronavirus Accessory Protein 8b Is Essential for Enhanced Virulence of an Attenuated Murine Coronavirus.

Yuming Li, Yingkang Jin, Lijun Kuang, Zhenhua Luo, Fang Li, Jing Sun, Airu Zhu, Zhen Zhuang, Yanqun Wang, Liyan Wen and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Yuming Li *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical Universitygrid.410737.6, Guangzhou, China.
Yingkang Jin *Pediatric Pulmonary Department, Guangzhou Women and Children's Medical Center, Guangzhou Medical Universitygrid.410737.6, Guangzhou, China.
Lijun Kuang *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical Universitygrid.410737.6, Guangzhou, China.
Zhenhua Luo *Institute of Precision Medicine, The First Affiliated Hospital, Sun Yat-sen Universitygrid.12981.33, Guangzhou, China.
Fang LiState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical Universitygrid.410737.6, Guangzhou, China.
Jing SunState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical Universitygrid.410737.6, Guangzhou, China.
Airu ZhuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical Universitygrid.410737.6, Guangzhou, China.
Zhen ZhuangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical Universitygrid.410737.6, Guangzhou, China.
Yanqun WangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical Universitygrid.410737.6, Guangzhou, China.
Liyan WenState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical Universitygrid.410737.6, Guangzhou, China.
Donglan LiuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical Universitygrid.410737.6, Guangzhou, China.
Chunke ChenState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical Universitygrid.410737.6, Guangzhou, China.
Mian GanState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical Universitygrid.410737.6, Guangzhou, China.
Jingxian ZhaoState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical Universitygrid.410737.6, Guangzhou, China.
Jincun ZhaoState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical Universitygrid.410737.6, Guangzhou, China.ORCID 0000-0003-2515-5589
First Affiliated Hospital of Guangzhou Medical University · CNGuangzhou Medical University · CNSun Yat-sen University · CN

Funding

Emergency Grants for Prevention and Control of SARS-CoV-2 of Ministry of Science and Technology of Guangdong Province 2020A111128008MOST | National Key Research and Development Program of China (NKRDPC) 2018YFC1200100National Natural Science Foundation of China (NSFC) 82002127National Natural Science Foundation of China (NSFC) 82025001National Science and Technology Major Project () 2018ZX10301403State Key Laboratory of Respiratory Disease (SKLRD) SKLRD-QN-201911
6 · The paper itself

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) is a beta coronavirus that emerged in 2012, causing severe pneumonia and renal failure. MERS-CoV encodes five accessory proteins. Some of them have been shown to interfere with host antiviral immune response. However, the roles of protein 8b in innate immunity and viral virulence was rarely studied. Here, we introduced individual MERS-CoV accessory protein genes into the genome of an attenuated murine coronavirus (Mouse hepatitis virus, MHV), respectively, and found accessory protein 8b could enhance viral replication

Indexed as

Protein Interaction Domains and MotifsAnimalsCoronavirus InfectionsHost-Pathogen InteractionsImmunity, InnateMiceMiddle East Respiratory Syndrome CoronavirusMortalityMurine hepatitis virusViral Regulatory and Accessory ProteinsViral TropismVirulenceVirulence FactorsViral Regulatory and Accessory ProteinsVirulence Factorsaccessory protein 8binnate immunityMERS-CoVvirulence

Identifiers

PMID34817197
PMCPMC8826903
OpenAlexW3215649412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.