Evidence map›Paper›PMID 34817175›Full record

ArticleACS chemical neuroscience2021

Development of a Dual Fluorescent and Magnetic Resonance False Neurotransmitter That Reports Accumulation and Release from Dopaminergic Synaptic Vesicles.

Michael R Post, Wei-Li Lee, Jia Guo, Dalibor Sames, David Sulzer

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael R PostDepartment of Psychiatry, Columbia University, Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, United States.
Wei-Li LeeDepartment of Chemistry, Columbia University, New York, New York 10027, United States.
Jia GuoDepartment of Psychiatry, Columbia University, Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, United States.
Dalibor SamesDepartment of Chemistry, Columbia University, New York, New York 10027, United States.ORCID 0000-0001-6911-2260
David SulzerDepartment of Psychiatry, Columbia University, Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, United States.ORCID 0000-0001-7632-0439

Funding

The Dopamine Synapse and Associative LearningR01DA007418 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David Sulzer · 1999 to 2026
$9.4M
Research Training in Late-Life NeuroPsychiatric DisordersT32MH020004 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Patrick J Brown · 1998 to 2026
$6.1M
Development of Fluorescent False NeurotransmittersR01MH108186 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SAMES, DALIBOR, SULZER, DAVID · 2015 to 2024
$5.8M
Development and Characterization of 19-Fluorine Magnetic Resonance Spectroscopy False Neurotransmitter ProbesK99MH122659 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI POST, MICHAEL ROBERT · 2020 to 2021
$255k
NIDA NIH HHS R01 DA007418NIMH NIH HHS K99 MH122659NIMH NIH HHS R01 MH108186NIMH NIH HHS T32 MH020004
6 · The paper itself

Abstract

Myriad neuropsychiatric disorders are due to dopamine dysfunction. However, understanding these disorders is limited by our ability to measure dopamine storage and release. Fluorescent false neurotransmitters (FFNs), small-molecule dyes that co-transit through the synaptic vesicle cycle, have allowed us to image dopamine in cell culture and acute brain slice, but

Indexed as

DopamineSynaptic VesiclesFluorescent DyesMagnetic Resonance SpectroscopyNeurotransmitter AgentsSynaptic TransmissionDopamineFluorescent DyesNeurotransmitter AgentsdopamineMRSneurotransmitter sensorParkinson’s diseasestriatumsynaptic vesicles

Identifiers

PMID34817175
PMCPMC8678980

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.