Evidence map›Paper›PMID 34817130›Full record

ArticleJournal of thrombosis and haemostasis : JTH2022

Thrombosis and thrombocytopenia after HPV vaccination.

Silje Johansen, Ingvild Jenssen Laegreid, Siw Leiknes Ernstsen, Nessar Ahmad Azrakhsh, Astrid Olsnes Kittang, Roald Lindås, Bjørn Tore Gjertsen, Nils Vetti, Trude Victoria Mørtberg, Ingvild Hausberg Sørvoll and 3 more

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Classification of Platelet-Activating Anti-Platelet Factor 4 Disorders.International journal of laboratory hematology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Anti-Platelet factor 4 immunothrombosis-not just heparin and vaccine triggers.Research and practice in thrombosis and haemostasis · 2025
    Review
  8. Review
  9. Article
  10. How We Interpret Thrombosis with Thrombocytopenia Syndrome?International journal of molecular sciences · 2024
    Review
  11. Review
  12. Low Incidence of Anti-PF4/Heparin Antibodies in Patients with Acute Myelogenous Leukemia.Mediterranean journal of hematology and infectious diseases · 2024
    Article
  13. Article
  14. Review
  15. Review
  16. How to approach acute thrombosis and thrombocytopenia.Clinical medicine (London, England) · 2023
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Silje JohansenSection of Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.ORCID 0000-0003-1373-2414
Ingvild Jenssen LaegreidThe Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Tromsø, Norway.ORCID 0000-0002-6379-4018
Siw Leiknes ErnstsenThe Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Tromsø, Norway.
Nessar Ahmad AzrakhshSection of Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Astrid Olsnes KittangSection of Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Roald LindåsSection of Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Bjørn Tore GjertsenSection of Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
Nils VettiDepartment of Radiology, Haukeland University Hospital, Bergen, Norway.
Trude Victoria MørtbergThe Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Tromsø, Norway.
Ingvild Hausberg SørvollThe Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Tromsø, Norway.
Pål André HolmeDepartment of Hematology, Oslo University Hospital, Norway.
Maria Therese AhlenThe Norwegian National Unit for Platelet Immunology, Division of Diagnostics, University Hospital of North Norway, Tromsø, Norway.ORCID 0000-0002-3104-3818
Håkon ReikvamSection of Hematology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.ORCID 0000-0001-5439-8411
Haukeland University Hospital · NOUniversity Hospital of North Norway · NOOslo University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVaccine-induced immune thrombotic thrombocytopenia (VITT) has so far only been reported after adenovirus vector severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines.

objectiveWe report findings in a 25-year-old woman who presented with thrombocytopenia, venous thrombosis, elevated D-dimer levels, and high levels of platelet-activating antibodies to platelet factor 4-polyanion complexes 10 days after Gardasil 9 vaccination for human papillomavirus (HPV). The patient exhibited clinical and laboratory features in line with the recently defined VITT syndrome, described after adenoviral vector vaccination to prevent coronavirus disease 2019.

conclusionWe report a case of VITT following HPV vaccination. This should raise awareness of the possibility of VITT also occurring after other vaccines, not exclusively adenoviral vector-based SARS-CoV-2 vaccines.

Indexed as

COVID-19Papillomavirus InfectionsThrombocytopeniaThrombosisAdultCOVID-19 VaccinesFemaleHumansSARS-CoV-2VaccinationCOVID-19 Vaccinesantibodieshematologythrombocytopeniathrombosisvaccines

Identifiers

PMID34817130
PMCPMC9906134
OpenAlexW3217252669

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.