Evidence map›Paper›PMID 34817012›Full record

ArticleArquivos brasileiros de cardiologia2021

C-reactive Protein as a Prognostic Marker of 1-Year Mortality after Transcatheter Aortic Valve Implantation in Aortic Stenosis.

André Luiz Silveira Sousa, Luiz Antônio Ferreira Carvalho, Constantino González Salgado, Rafael Lauria de Oliveira, Luciana Cristina Correia Lima E Lima, Nelson Durval Ferreira Gomes de Mattos, Francisco Eduardo Sampaio Fagundes, Alexandre Siciliano Colafranceschi, Evandro Tinoco Mesquita

Open access · diamondAbstract read
In one paragraph

Article in Arquivos brasileiros de cardiologia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  5. Article
  6. Review
  7. The Role of Inflammation in Post-TAVI Outcomes.Arquivos brasileiros de cardiologia · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

André Luiz Silveira SousaUniversidade Federal Fluminense - Hospital Antonio Pedro - Cardiologia, Niterói, RJ - Brasil.ORCID 0000-0001-7647-9124
Luiz Antônio Ferreira CarvalhoHospital Pró-Cardíaco - Hemodinâmica, Rio de Janeiro, RJ - Brasil.
Constantino González SalgadoHospital Pró-Cardíaco - Hemodinâmica, Rio de Janeiro, RJ - Brasil.
Rafael Lauria de OliveiraHospital Pró-Cardíaco - Hemodinâmica, Rio de Janeiro, RJ - Brasil.
Luciana Cristina Correia Lima E LimaHospital Pró-Cardíaco - Hemodinâmica, Rio de Janeiro, RJ - Brasil.
Nelson Durval Ferreira Gomes de MattosHospital Pró-Cardíaco - Hemodinâmica, Rio de Janeiro, RJ - Brasil.
Francisco Eduardo Sampaio FagundesHospital Pró-Cardíaco - Hemodinâmica, Rio de Janeiro, RJ - Brasil.
Alexandre Siciliano ColafranceschiHospital Pró-Cardíaco - Hemodinâmica, Rio de Janeiro, RJ - Brasil.ORCID 0000-0003-0955-9225
Evandro Tinoco MesquitaUniversidade Federal Fluminense - Hospital Antonio Pedro - Cardiologia, Niterói, RJ - Brasil.
Hospital Pró-Cardíaco · BRUniversidade Federal Fluminense · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundC-reactive protein (CRP) is an inflammation biomarker that can be a predictor of adverse events in cardiovascular procedures. Its use in the assessment of long-term prognosis of transcatheter aortic valve implantation (TAVI) is still incipient.

objectiveTo evaluate CRP as a prognostic marker in the first year after TAVI in aortic stenosis (AoS).

methodsCRP was assessed on the first postoperative week in a retrospective cohort of patients with AoS. Pre- and post- CRP levels were correlated with mortality, and predictors of 1-year mortality were investigated. Multivariate Cox regression was performed to identify independent factors of 1-year mortality.

resultsThis study evaluated 130 patients who underwent TAVI, with median age of 83 years, and 49% of women. High pre-TAVI CRP (> 0.5 mg/dL) was observed in 34.5% of the cases. Peak CRP was 7.0 (5.3-12.1) mg/dL no quarto dia. The rate of 1-year mortality was 14.5% (n = 19), being greater in the groups with high pre-TAVI CRP (68.8% vs 29.1%; p = 0,004) and with peak CRP ≥ 10.0 mg/dL (64.7% vs 30.8%; p = 0,009). Independent predictors of mortality were acute renal failure (ARF) (hazard ratio [HR] = 7.43; 95% confidence interval [95%CI], 2.1-24.7; p = 0,001), high pre-TAVI CRP (HR 4.15; 95%CI, 1.3-12.9; p = 0.01), and large blood transfusion [HR 4,68; 1,3-16,7; p = 0.02].

conclusionsHigh pre-TAVI CRP showed to be an independent predictor of 1-year mortality, as well as the presence of ARF and large blood transfusions.

Indexed as

Aortic Valve StenosisTranscatheter Aortic Valve ReplacementAged, 80 and overAortic ValveC-Reactive ProteinFemaleHumansMalePrognosisRetrospective StudiesRisk FactorsTreatment OutcomeC-Reactive Protein

Identifiers

PMID34817012
PMCPMC8682084
OpenAlexW3212490118

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.