Evidence map›Paper›PMID 34816756›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2022

Fecal microbiome and bile acid metabolome in adult short bowel syndrome.

Harold J Boutte, Jacqueline Chen, Todd N Wylie, Kristine M Wylie, Yan Xie, Mackenzie Geisman, Anirudh Prabu, Vered Gazit, Phillip I Tarr, Marc S Levin and 3 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Metabolites · 2023
    Article
  14. Article
  15. Article
  16. Review
  17. Bile acids and salt-sensitive hypertension: a role of the gut-liver axis.American journal of physiology. Heart and circulatory physiology · 2022
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Harold J BoutteDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Jacqueline ChenDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Todd N WylieDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Kristine M WylieDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Yan XieDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Mackenzie GeismanDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Anirudh PrabuDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Vered GazitDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Phillip I TarrDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Marc S LevinDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Brad W WarnerDivision of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri.
Nicholas O DavidsonDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Deborah C RubinDivision of Gastroenterology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.ORCID 0000-0002-4192-909X
Washington University in St. Louis · USJames S. McDonnell Foundation · US

Funding

Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
CLINICAL/LABORATORY TRAINING ACADEMIC GASTROENTEROLOGYT32DK007130 · NIDDK · WASHINGTON UNIVERSITY · PI MATTHEW AARON CIORBA · 1986 to 2026
$8.3M
Impaired VLDL secretion, progression and reversal of hepatic fibrogenesisR01DK119437 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2019 to 2026
$3.8M
MYOFIBROBLAST REGULATION OF THE STEM CELL NICHE IN SHORT BOWEL SYNDROMER01DK106382 · NIDDK · WASHINGTON UNIVERSITY · PI RUBIN, DEBORAH C. · 2015 to 2018
$1.4M
Bile acid metabolomics and metagenomics in short bowel syndromeR01DK112378 · NIDDK · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O., RUBIN, DEBORAH C. · 2016 to 2018
$1.1M
HHS | National Institutes of Health (NIH) CA23289HHS | National Institutes of Health (NIH) NIDDK T3207130NIDDK NIH HHS P30 DK052574NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK106382NIDDK NIH HHS R01 DK112378NIDDK NIH HHS R01 DK119437NIDDK NIH HHS T32 DK007130
6 · The paper itself

Abstract

Loss of functional small bowel surface area causes short bowel syndrome (SBS), intestinal failure, and parenteral nutrition (PN) dependence. The gut adaptive response following resection may be difficult to predict, and it may take up to 2 yr to determine which patients will wean from PN. Here, we examined features of gut microbiota and bile acid (BA) metabolism in determining adaptation and ability to wean from PN. Stool and sera were collected from healthy controls and from patients with SBS (

Indexed as

Adaptation, PhysiologicalBile Acids and SaltsChromatography, LiquidFecesGastrointestinal MicrobiomeHumansIntestine, SmallMetabolomeMicrobiotaRNA, Ribosomal, 16SShort Bowel SyndromeBile Acids and SaltsRNA, Ribosomal, 16Senterohepatic bile acid cyclingFGF19intestinal adaptationshort gut syndrome

Identifiers

PMID34816756
PMCPMC8793869
OpenAlexW3216064153

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.