Evidence map›Paper›PMID 34816611›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Fine Particulate Matter Induces Childhood Asthma Attacks via Extracellular Vesicle-Packaged Let-7i-5p-Mediated Modulation of the MAPK Signaling Pathway.

Rui Zheng, Mulong Du, Man Tian, Zhaozhong Zhu, Chengcheng Wei, Haiyan Chu, Cong Gan, Jiayuan Liang, Renjie Xue, Fang Gao and 3 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Review
  2. Distinct miRNA expression patterns in circulating eosinophil subtypes and their subtype-derived exosomes in allergic asthma.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  3. Review
  4. How PMLife medicine · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Observational
  9. Journal of oral microbiology · 2025
    Article
  10. Article
  11. Particulate matter-induced epigenetic modifications and lung complications.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  12. Functions and Clinical Applications of Extracellular Vesicles in TInternational journal of molecular sciences · 2024
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rui ZhengDepartment of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Mulong DuDepartment of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, 211166, China.
Man TianDepartment of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China.
Zhaozhong ZhuDepartment of Emergency Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Chengcheng WeiDepartment of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Haiyan ChuDepartment of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Cong GanDepartment of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China.
Jiayuan LiangDepartment of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Renjie XueDepartment of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China.
Fang GaoDepartment of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Zhenguang MaoDepartment of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Meilin WangDepartment of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Zhengdong ZhangDepartment of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.ORCID 0000-0003-0190-8574

Funding

China Postdoctoral Science Foundation 2020M681673National Natural Science Foundation of China 81973095National Natural Science Foundation of China 82130096Natural Science Foundation of Jiangsu Province BE2019729Natural Science Foundation of Jiangsu Province BK20181120Priority Academic Program Development of Jiangsu Higher Education Institutions (Public Health and Preventive Medicine)
6 · The paper itself

Abstract

Fine particulate matter less than 2.5 µm in diameter (PM

Indexed as

AnimalsAsthmaChildDisease Models, AnimalExtracellular VesiclesFemaleHumansMAP Kinase Signaling SystemMiceMice, Inbred BALB CMicroRNAsParticulate MatterSignal TransductionMicroRNAsmirnlet7 microRNA, humanParticulate Matterchildhood asthmaextracellular vesicleslet-7i-5pMAPK signaling pathwayPM2.5

Identifiers

PMID34816611
PMCPMC8787417

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.