Evidence map›Paper›PMID 34816425›Full record

ArticleEpilepsia2022

Simulated driving in the epilepsy monitoring unit: Effects of seizure type, consciousness, and motor impairment.

Avisha Kumar, Reese Martin, William Chen, Andrew Bauerschmidt, Mark W Youngblood, Courtney Cunningham, Yang Si, Cel Ezeani, Zachary Kratochvil, Jared Bronen and 8 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Epilepsia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Avisha KumarDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Reese MartinDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
William ChenDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Andrew BauerschmidtDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Mark W YoungbloodDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Courtney CunninghamDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Yang SiDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0003-3541-939X
Cel EzeaniDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Zachary KratochvilDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Jared BronenDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
James ThomsonDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Katherine RiordanDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Ji Yeoun YooDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0001-7242-9779
Romina ShirkaDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Louis ManganasDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Heinz KrestelDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0001-8742-0232
Lawrence J HirschDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.
Hal BlumenfeldDepartment of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0003-0812-8132
Yale University · USGoethe University Frankfurt · DE

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Functional Neuroimaging in Childhood Absence EpilepsyR01NS055829 · NINDS · YALE UNIVERSITY · PI BLUMENFELD, HAL · 2006 to 2016
$3.2M
NCATS NIH HHS UL1 TR001863NINDS NIH HHS R01 NS055829
6 · The paper itself

Abstract

People with epilepsy face serious driving restrictions, determined using retrospective studies. To relate seizure characteristics to driving impairment, we aimed to study driving behavior during seizures with a simulator. Patients in the Yale New Haven Hospital undergoing video-electroencephalographic monitoring used a laptop-based driving simulator during ictal events. Driving function was evaluated by video review and analyzed in relation to seizure type, impairment of consciousness/responsiveness, or motor impairment during seizures. Fifty-one seizures in 30 patients were studied. In terms of seizure type, we found that focal to bilateral tonic-clonic or myoclonic seizures (5/5) and focal seizures with impaired consciousness/responsiveness (11/11) always led to driving impairment; focal seizures with spared consciousness/responsiveness (0/10) and generalized nonmotor (generalized spike-wave bursts; 1/19) usually did not lead to driving impairment. Regardless of seizure type, we found that seizures with impaired consciousness (15/15) or with motor involvement (13/13) always led to impaired driving, but those with spared consciousness (0/20) or spared motor function (5/38) usually did not. These results suggest that seizure types with impaired consciousness/responsiveness and abnormal motor function contribute to impaired driving. Expanding this work in a larger cohort could further determine how results with a driving simulator may translate into real world driving safety.

Indexed as

EpilepsyMotor DisordersConsciousnessElectroencephalographyHumansRetrospective StudiesSeizuresconsciousnessdriving simulationEEGepilepsyseizuretonic-clonic

Identifiers

PMID34816425
PMCPMC8883409
OpenAlexW3216791206

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.