Evidence map›Paper›PMID 34816400›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Use of a Ferret Model to Test Efficacy and Immunogenicity of Live Attenuated Mycobacterium avium Subspecies paratuberculosis Vaccines.

John P Bannantine, Tuhina Gupta, Denise K Zinniel, Ahmed Hikal, Frederick D Quinn, Raul G Barletta

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

John P BannantineNational Animal Disease Center, USDA-ARS, Ames, IA, USA. john.bannantine@usda.gov.
Tuhina GuptaUniversity of Georgia, College of Veterinary Medicine, Athens, GA, USA.
Denise K ZinnielUniversity of Nebraska-Lincoln, School of Veterinary Medicine and Biomedical Sciences, Lincoln, NE, USA.
Ahmed HikalUniversity of Georgia, College of Veterinary Medicine, Athens, GA, USA.
Frederick D QuinnUniversity of Georgia, College of Veterinary Medicine, Athens, GA, USA.
Raul G BarlettaUniversity of Nebraska-Lincoln, School of Veterinary Medicine and Biomedical Sciences, Lincoln, NE, USA.
University of Georgia · USUniversity of Nebraska–Lincoln · USGeorgia College & State University · USNational Animal Disease Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Native hosts for the bacterial agent that causes Johne's disease are ruminants, which include cattle, sheep and goats among others. These large animals are often too costly to be used in testing experimental vaccines. In this chapter, we provide detailed methods to use an inexpensive and more manageable animal host, the ferret, to test efficacy and immunogenicity of live-attenuated Mycobacterium avium subspecies paratuberculosis (MAP) mutant strains prior to consideration as vaccine candidates.

Indexed as

Mycobacterium avium subsp. paratuberculosisParatuberculosisAnimalsBacterial VaccinesCattleFerretsSheepVaccines, AttenuatedBacterial VaccinesVaccines, AttenuatedAnimal modelFerretsJohne’s diseaseMycobacteriumParatuberculosis

Identifiers

PMID34816400
OpenAlexW3215270478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.