Evidence map›Paper›PMID 34816383›Full record

ReviewDermatology and therapy2022

Dermatologic Events Associated with the Anti-CCR4 Antibody Mogamulizumab: Characterization and Management.

Amy C M Musiek, Kerri E Rieger, Martine Bagot, Jennifer N Choi, David C Fisher, Joan Guitart, Paul L Haun, Steven M Horwitz, Auris Onn-Lay Huen, Bernice Y Kwong and 6 more

Open access · goldAbstract readReview
In one paragraph

Review in Dermatology and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Acneiform type of mogamulizumab-associated rash.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025
    Article
  5. Article
  6. Review
  7. Practical recommendations for therapy and monitoring of mogamulizumab patients in Germany.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025
    Review
  8. [Exanthematic drug eruption].Pathologie (Heidelberg, Germany) · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Clinical and Real-World Effectiveness of Mogamulizumab: A Narrative Review.International journal of molecular sciences · 2024
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 3 countries.

Amy C M MusiekDivision of Dermatology, Washington University School of Medicine, 4901 Forest Park, Suite 502, Saint Louis, MO, 63108, USA. amusiek@wustl.edu.
Kerri E RiegerStanford University, Stanford, CA, USA.
Martine BagotHôpital Saint Louis, APHP, Inserm U976, Université de Paris, Paris, France.
Jennifer N ChoiNorthwestern University, Evanston, IL, USA.
David C FisherDana-Farber Cancer Institute, Boston, MA, USA.
Joan GuitartNorthwestern University, Evanston, IL, USA.
Paul L HaunUniversity of Pennsylvania, Philadelphia, PA, USA.
Steven M HorwitzMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Auris Onn-Lay HuenMD Anderson Cancer Center, Houston, TX, USA.
Bernice Y KwongStanford University, Stanford, CA, USA.
Mario E LacoutureMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Sarah J NoorMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Alain H RookUniversity of Pennsylvania, Philadelphia, PA, USA.
Lucia Seminario-VidalUniversity of South Florida and H. Lee Moffitt Cancer Center, Tampa, FL, USA.
Maarten H VermeerLeiden University, Leiden, The Netherlands.
Youn H KimStanford University, Stanford, CA, USA.
Memorial Sloan Kettering Cancer Center · USStanford University · USNorthwestern University · USUniversity of Pennsylvania · USDana-Farber Cancer Institute · USLeiden University · NLMoffitt Cancer Center · USThe University of Texas MD Anderson Cancer Center · USUniversité Paris Cité · FRWashington University in St. Louis · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

The CCR4-directed monoclonal antibody mogamulizumab has been shown to significantly improve progression-free survival and overall response rate compared with vorinostat in adults with relapsed/refractory mycosis fungoides (MF) and Sézary syndrome (SS). One of the most common adverse events seen with mogamulizumab in MF/SS patients is rash. Because of the protean nature of MF/SS and the variable clinical and histopathological features of mogamulizumab-associated rash, healthcare providers may have difficulty distinguishing rash from disease, and may not be aware of appropriate treatment strategies for this generally manageable adverse event. The objective of this report was to combine results from published literature with experiences and recommendations from multiple investigators and institutions into clinical best practice recommendations to assist healthcare providers in identifying and managing mogamulizumab-associated rash. Optimal management, which includes biopsy confirmation and steroid treatment, requires a multidisciplinary approach among oncology, dermatology, and pathology practitioners. INFOGRAPHIC.

Indexed as

Cutaneous T-cell lymphomaEruptionMogamulizumabMycosis fungoidesRashSézary syndrome

Identifiers

PMID34816383
PMCPMC8776934
OpenAlexW3216665611

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.