Evidence map›Paper›PMID 34816378›Full record

ArticleCardiovascular engineering and technology2022

During Early VF in Rabbit Hearts, His Bundle Pacing is Less Effective Than Working Myocardial Pacing in Modulating Left Ventricular Activation Rates.

Ankur R Shah, Muhammad S Khan, Matthias Lange, Annie M Hirahara, Gregory Stoddard, Ravi Ranjan, Derek J Dosdall

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular engineering and technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ankur R ShahDepartment of Biomedical Engineering, The University of Utah, Salt Lake City, UT, 84112, USA.
Muhammad S KhanNora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah, Salt Lake City, UT, 84112, USA.
Matthias LangeNora Eccles Harrison Cardiovascular Research and Training Institute, The University of Utah, Salt Lake City, UT, 84112, USA.
Annie M HiraharaDepartment of Biomedical Engineering, The University of Utah, Salt Lake City, UT, 84112, USA.
Gregory StoddardDivision of Epidemiology, School of Medicine, The University of Utah, Salt Lake City, UT, 84112, USA.
Ravi RanjanDepartment of Biomedical Engineering, The University of Utah, Salt Lake City, UT, 84112, USA.
Derek J DosdallDepartment of Biomedical Engineering, The University of Utah, Salt Lake City, UT, 84112, USA. derek.dosdall@utah.edu.ORCID 0000-0001-5059-6824
University of Utah · US

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
TRAINING IN CARDIOVASCULAR RESEARCHT32HL007576 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Stavros George Drakos, Robin M Shaw · 1985 to 2026
$10.6M
His-Purkinje Pacing for Low Energy Implantable Cardioverter DefibrillatorsR01HL128752 · NHLBI · UNIVERSITY OF UTAH · PI DOSDALL, DEREK J · 2015 to 2024
$5.0M
Myocardial Substrate Driven Mechanistic Insights into Atrial FibrillationR01HL142913 · NHLBI · UNIVERSITY OF UTAH · PI RANJAN, RAVI · 2018 to 2021
$2.4M
Novel lead for selective His bundle sensing and low-threshold pacingR21HL156039 · NHLBI · UNIVERSITY OF UTAH · PI DOSDALL, DEREK J · 2021 to 2022
$419k
NCATS NIH HHS UL1 TR002538NHLBI NIH HHS R01 HL128752NHLBI NIH HHS R01 HL142913NHLBI NIH HHS R21 HL156039NHLBI NIH HHS T32 HL007576
6 · The paper itself

Abstract

purposeThe potential of pacing and capturing the His-Purkinje system (HPS) to synchronize VF wavefronts is not known even though the HPS is thought to be electrically linked during VF. In this study the effect of selective His Bundle (HB) pacing was compared with nearby working myocardial (WM) pacing on the left ventricular (LV) endocardial activation rates.

methodsRabbit hearts (n = 9) were explanted and Langendorff perfused. Electrodes directly on the HB were identified and paced subsequently using an electrode array. The WM was paced through a silver wire inserted in the right ventricular septal wall. After VF was induced, the HB was paced at rates faster than the intrinsic HB activation rate (n = 18 episodes) and also at rates faster than the LV activation rate (n = 16). A basket array inserted in the LV was used to record electrograms before and during each pacing episode. Activation rates at five LV electrodes each from the earliest and latest activating sinus rhythm regions were analyzed before and during pacing.

resultsBoth HB and WM pacing reduced LV activation rates during pacing, but WM pacing was more effective (p < 0.005). WM pacing events were more effective (p < 0.05) in reducing LV activation rates than HB pacing in episodes which were faster than LV activation rates.

conclusionThis study provides evidence that during early VF in rabbit hearts, the HPS cannot be driven to effectively modulate the LV activation rates.

Indexed as

Bundle of HisCardiac Pacing, ArtificialAnimalsHeart VentriclesMyocardiumRabbitsHis BundleHis–Purkinje systemMappingPacingVentricular arrhythmia

Identifiers

PMID34816378
PMCPMC9124730
OpenAlexW3214784869

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.