Evidence map›Paper›PMID 34816331›Full record

ArticleMikrochimica acta2021

SERS-based immunoassay based on gold nanostars modified with 5,5'-dithiobis-2-nitrobenzoic acid for determination of glial fibrillary acidic protein.

Peng Zhao, Jingyi Sun, Shijun Zhao, Yanan Song, Feng Gao, Hongbin Wang, Qingbin Ni, Ying Wang, Baoliang Sun

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Peng ZhaoDepartment of Neurology, Second Affiliated Hospital, Institute for Neurological Research & Key Laboratory of Cerebral Microcirculation, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, Shandong, China.
Jingyi SunShandong Provincial Hospital Affiliated To Shandong First Medical University& Shandong Academy of Medical Sciences, Jinan, 250021, Shandong, China.
Shijun ZhaoDepartment of Neurology, Baotou Central Hospital, Baotou, 014040, Neimenggu, China.
Yanan SongQingdao Medical College of Qingdao University, Qingdao, 266021, Shandong, China.
Feng GaoDepartment of Neurology, Second Affiliated Hospital, Institute for Neurological Research & Key Laboratory of Cerebral Microcirculation, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, Shandong, China.
Hongbin WangDepartment of Neurology, Second Affiliated Hospital, Institute for Neurological Research & Key Laboratory of Cerebral Microcirculation, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, Shandong, China.
Qingbin NiPostdoctoral Workstation, Taian Central Hospital, Taian, 271000, Shandong, China.
Ying WangDepartment of Neurology, Second Affiliated Hospital, Institute for Neurological Research & Key Laboratory of Cerebral Microcirculation, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, Shandong, China. yingw9@163.com.ORCID http://orcid.org/0000-0002-6652-7636
Baoliang SunDepartment of Neurology, Second Affiliated Hospital, Institute for Neurological Research & Key Laboratory of Cerebral Microcirculation, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, 271000, Shandong, China.
Shandong First Medical University · CNBaotou Central Hospital · CNQingdao University · CNShandong Provincial Hospital · CNTaian City Central Hospital · CN

Funding

natural science foundation of china NO.81870938
6 · The paper itself

Abstract

A surface-enhanced Raman scattering (SERS)-based immunoassay with gold nanostars (GNSs) is utilized for determination of the subarachnoid hemorrhage (SAH) biomarker glial fibrillary acidic protein (GFAP) at very low concentration levels, which allows for early diagnosis and guides clinical decision-making to treat SAH-induced complications. The Raman reporter 5,5'-dithiobis-2-nitrobenzoic acid (DTNB) modified on GNSs was selected as the SERS tags. The SERS immunoassay was assembled by SERS tag and GFAP probe-immobilized ITO substrate. Therefore, the level of GFAP can be detected by monitoring the characteristic Raman peak intensity of GFAP-conjugated GNSs at 1332 cm

Indexed as

Biosensing TechniquesEnzyme-Linked Immunosorbent AssayGlial Fibrillary Acidic ProteinGoldHumansImmunoassaySpectrum Analysis, RamanGlial Fibrillary Acidic ProteinGoldGFAPGNSsGold nanoparticlesSERSSubarachnoid hemorrhage

Identifiers

PMID34816331
OpenAlexW3217012436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.