Evidence map›Paper›PMID 34816310›Full record

ArticleClinical oral investigations2022

Effects of the association of high fluoride- and calcium-containing caries-preventive agents with regular or high fluoride toothpaste on enamel: an in vitro study.

Richard Johannes Wierichs, Judith Mester, Thomas Gerhard Wolf, Hendrik Meyer-Lueckel, Marcella Esteves-Oliveira

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Richard Johannes WierichsDepartment of Restorative, Preventive and Pediatric Dentistry, zmk bern, University of Bern, Freiburgstrasse 7, CH-3010, Bern, Switzerland. Richard.wierichs@zmk.unibe.ch.ORCID http://orcid.org/0000-0002-4239-199X
Judith MesterDepartment of CariologyEndodontology and Periodontology, University of Leipzig, Liebigstraße 12, 04103, Leipzig, Germany.
Thomas Gerhard WolfDepartment of Restorative, Preventive and Pediatric Dentistry, zmk bern, University of Bern, Freiburgstrasse 7, CH-3010, Bern, Switzerland.
Hendrik Meyer-LueckelDepartment of Restorative, Preventive and Pediatric Dentistry, zmk bern, University of Bern, Freiburgstrasse 7, CH-3010, Bern, Switzerland.
Marcella Esteves-OliveiraDepartment of Restorative, Preventive and Pediatric Dentistry, zmk bern, University of Bern, Freiburgstrasse 7, CH-3010, Bern, Switzerland.
University of Bern · CHLeipzig University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim of this in vitro study was to compare the caries-preventive effect of various high fluoride- and calcium-containing caries-preventive agents (> 22.000 ppm F MATERIALS AND

methodsBovine enamel specimens (n = 276; 5 mm × 3.5 mm × 3 mm) having one sound surface [ST] and one artificial caries lesion [DT] were randomly allocated to 12 groups. Interventions before pH-cycling were no intervention ([SC

resultsAfter pH-cycling, SC

conclusionUnder the conditions chosen, all fluoride varnishes/solutions significantly reduced demineralization. Furthermore, a significant dose-response characteristic for fluoride varnishes could be revealed. However, no additional benefit could be observed, when varnishes were combined with high fluoride instead of regular fluoride dentifrices. CLINICAL RELEVANCE: For children and adolescents with high caries risks varnishes containing more than 22,600 ppm should be further investigated, as they offered higher caries-preventive effects in vitro. Furthermore, there seems to be no difference in the demineralization-inhibitory capacity of fluoride varnishes when used in combination with either standard or highly fluoridated dentifrices.

Indexed as

Dental CariesDentifricesAdolescentAnimalsCalciumCariostatic AgentsCattleChildDental Caries SusceptibilityDental EnamelFluoridesHumansSodium FluorideToothpastesTooth RemineralizationCalciumCariostatic AgentsDentifricesFluoridesSodium FluorideToothpastesCPP-ACPDemineralizationEnamelFluorideIn vitropH-cyclingSDFVarnish

Identifiers

PMID34816310
OpenAlexW3217468292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.