Evidence map›Paper›PMID 34816305›Full record

Observational studySurgical endoscopy2022

Efficacy of polyglycolic acid sheeting with fibrin glue for perforations related to gastrointestinal endoscopic procedures: a multicenter retrospective cohort study.

Kengo Takimoto, Noriko Matsuura, Yoshiko Nakano, Yosuke Tsuji, Kohei Takizawa, Yoshinori Morita, Yasuaki Nagami, Kingo Hirasawa, Hiroshi Araki, Naoyuki Yamaguchi and 13 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Surgical endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Kengo TakimotoDepartment of Gastroenterology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan. k-takimoto-kengo-1209-1209@y8.dion.ne.jp.ORCID http://orcid.org/0000-0002-0157-0385
Noriko MatsuuraDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
Yoshiko NakanoDepartment of Gastroenterology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Yosuke TsujiDepartment of Gastroenterology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
Kohei TakizawaDivision of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
Yoshinori MoritaDepartment of Gastroenterology, International Clinical Cancer Research Center, Kobe University Hospital, Kobe, Japan.
Yasuaki NagamiDepartment of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Kingo HirasawaDivision of Endoscopy, Yokohama City University Medical Center, Yokohama, Japan.
Hiroshi ArakiDepartment of Gastroenterology, Gifu University Hospital, Gifu, Japan.
Naoyuki YamaguchiDepartment of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, Japan.
Hiroyuki AoyagiDepartment of Gastroenterology, Fukui Prefectural Hospital, Fukui, Japan.
Tamotsu MatsuhashiDepartment of Gastroenterology, Akita University Graduate School of Medicine, Akita, Japan.
Toshiro IizukaDepartment of Gastroenterology, Toranomon Hospital, Tokyo, Japan.
Hisanobu SaegusaDepartment of Gastroenterology, Shinonoi General Hospital, Nagano, Japan.
Kenji YamazakiDepartment of Gastroenterology, Gifu Prefectural General Medical Center, Gifu, Japan.
Shinichiro HoriDepartment of Internal Medicine, Shikoku Cancer Center, Ehime, Japan.
Tomohiko MannamiDepartment of Gastroenterology, Chugoku Central Hospital, Fukuyama, Japan.
Noboru HanaokaDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
Hirohito MoriDepartment of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Hideki KobaraDepartment of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Yoji TakeuchiDepartment of Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, Japan.
Hiroyuki OnoDivision of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.
Polyglycolic Acid Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesGastrointestinal (GI) perforations are one of the major adverse events of endoscopic procedures. Polyglycolic acid (PGA) sheets with fibrin glue have been reported to close GI perforations. However, its clinical outcome has not yet been fully investigated; thus, we conducted a multicenter retrospective observational study to assess the efficacy of PGA sheeting for GI perforation.

methodsThe medical records of patients who underwent PGA sheeting for endoscopic GI perforations between April 2013 and March 2018 in 18 Japanese institutions were retrospectively analyzed. PGA sheeting was applied when the clip closure was challenging or failed to use. Perforations were filled with one or several pieces of PGA sheets followed by fibrin glue application through an endoscopic catheter. Nasal or percutaneous drainage and endoscopic clipping were applied as appropriate. Clinical outcomes after PGA sheeting for intraoperative or delayed perforations were separately evaluated.

resultsThere were 66 intraoperative and 24 delayed perforation cases. In intraoperative cases, successful closure was attained in 60 cases (91%). The median period from the first sheeting to diet resumption was 6 days (interquartile range [IQR], 4-8.8 days). Large perforation size (≥ 10 mm) and duodenal location showed marginal significant relationship to higher closure failure of intraoperative perforations. In delayed perforation cases, all cases had successful closure. The median period from the first sheeting to diet resumption was 10 days (IQR, 6-37.8 days). No adverse events related to PGA sheeting occurred.

conclusionEndoscopic PGA sheeting could be a therapeutic option for GI perforations related to GI endoscopic procedures.

Indexed as

Fibrin Tissue AdhesiveTissue AdhesivesEndoscopy, GastrointestinalHumansPolyglycolic AcidRetrospective StudiesTreatment OutcomeFibrin Tissue AdhesivePolyglycolic AcidTissue AdhesivesDrainageEndoscopyFibrin glueGastrointestinal perforationPolyglycolic acid sheet

Identifiers

PMID34816305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.