Evidence map›Paper›PMID 34816290›Full record

ArticlePsychopharmacology2022

Effects of repeated treatment with the 5-HT

Sanders A McDougall, Jordan A Taylor, Matthew J Roe, Constance J Greenwood

Abstract read
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In one paragraph

Article in Psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sanders A McDougallDepartment of Psychology, California State University, 5500 University Parkway, San Bernardino, CA, 92407, USA. smcdouga@csusb.edu.ORCID http://orcid.org/0000-0002-4194-9744
Jordan A TaylorDepartment of Psychology, California State University, 5500 University Parkway, San Bernardino, CA, 92407, USA.
Matthew J RoeDepartment of Psychology, California State University, 5500 University Parkway, San Bernardino, CA, 92407, USA.
Constance J GreenwoodDepartment of Psychology, California State University, 5500 University Parkway, San Bernardino, CA, 92407, USA.
California State University, San Bernardino · US

Funding

Foundation for the National Institutes of Health GM136467
6 · The paper itself

Abstract

rationaleDrugs that stimulate 5-HT

objectiveThe purpose of this study was to determine whether repeated treatment with selective 5-HT

methodsIn Experiments 1 and 2, male and female preweanling rats were given a single pretreatment injection of saline, the 5-HT

resultsOn the first pretreatment day, 8-OH-DPAT, CP-94253, and DPAT + CP increased locomotion and caused hypothermia. Repeated treatment with 8-OH-DPAT (2 or 8 mg/kg) or DPAT + CP caused locomotor sensitization in preweanling rats. In contrast, tolerance to the hypothermic effects of 8-OH-DPAT (8 mg/kg), CP-94253 (5-20 mg/kg), or DPAT + CP was evident after repeated drug treatment.

conclusionsDuring the preweanling period, a single injection of a selective 5-HT

Indexed as

Behavior, AnimalSerotonin8-Hydroxy-2-(di-n-propylamino)tetralinAnimalsFemaleLocomotionMaleMiceMotor ActivityRatsTemperature8-Hydroxy-2-(di-n-propylamino)tetralinSerotoninBehavioral sensitizationCP-94253HypothermiaLocomotor activity(R)-( +)-8-Hydroxy-DPAT (8-OH-DPAT)Tolerance

Identifiers

PMID34816290
OpenAlexW3215030158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.