Evidence map›Paper›PMID 34816289›Full record

ArticlePsychopharmacology2022

Effects of OPRM1 and DRD2 on brain structure in drug-naïve adolescents: Genetic and neural vulnerabilities to substance use.

Giorgia Picci, Diana H Fishbein, John W VanMeter, Emma J Rose

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review.International journal of environmental research and public health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Giorgia PicciInstitute for Human Neuroscience, Boys Town National Research Hospital, 378 Bucher Drive, Boys Town, NE, 68010, USA. giorgia.picci@boystown.org.ORCID http://orcid.org/0000-0002-0700-4739
Diana H FishbeinDepartment of Human Development and Family Studies, Program for Translational Research On Adversity and Neurodevelopment (P-TRAN), Edna Bennett Pierce Prevention Research Center, Penn State University, 218 Health and Human Development Building, University Park, PA, 16802, USA.
John W VanMeterCenter for Functional and Molecular Imaging, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, DC, 20057, USA.
Emma J RoseProgram for Translational Research On Adversity and Neurodevelopment (P-TRAN), Edna Bennett Pierce Prevention Research Center, Penn State University, 310A Biobehavioral Health Building, University Park, PA, 16802, USA.
Pennsylvania State University · USBoys Town · USGeorgetown University · US

Funding

NEUROIMAGING COREP30HD040677 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI MCCARTER, ROBERT JAMES · 2001 to 2015
$15.9M
Reading and sensorimotor fluency in dyslexiaP50HD040095 · NICHD · GEORGETOWN UNIVERSITY · PI EDEN, GUINEVERE F. · 2001 to 2006
$7.5M
Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2016 to 2020
$5.9M
Developmental fMRI Study of Alcohol Use in AdolescenceR01AA019983 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI FISHBEIN, DIANA H, VANMETER, ASHLEY S · 2011 to 2015
$3.4M
NIAAA NIH HHS 1R01AA019983-01NIAAA NIH HHS 3R01AA019983-02S1NIAAA NIH HHS R01 AA019983NICHD NIH HHS P30 HD040677NICHD NIH HHS P50 HD040095NICHD NIH HHS U54 HD090257
6 · The paper itself

Abstract

Genetic variants in the opioid receptor mu 1 (OPRM1) and dopamine receptor d2 (DRD2) genes are implicated in behavioral phenotypes related to substance use disorders (SUD). Despite associations among OPRM1 (rs179971) and DRD2 (rs6277) genes and structural alterations in neural reward pathways implicated in SUDs, little is known about the contribution of risk-related gene variants to structural neurodevelopment. In a 3-year longitudinal study of initially SU-naïve adolescents (N = 129; 70 females; 11-14 years old), participants underwent an MRI structural scan at baseline and provided genetic assays for OPRM1 and DRD2 with SU behavior assessed during follow-up visits. Baseline differences in key reward-related brain regions (i.e., bilateral caudate and cingulate cortex) were detected in those with genetic liability for SU in OPRM1 who went onto engage in SU at subsequent waves of data collection. In addition, main effects of OPRM1, DRD2, and SU were related to variability in structure of the putamen, anterior cingulate, and nucleus accumbens, respectively. These data provide preliminary evidence that genetic risk factors interact with future SU to confer structural variability prior to SU in regions commonly implicated in risk for SU and the development of SUDs.

Indexed as

Pharmaceutical PreparationsSubstance-Related DisordersAdolescentBrainChildFemaleHumansLongitudinal StudiesMaleReceptors, Dopamine D2Receptors, Opioid, muDRD2 protein, humanOPRM1 protein, humanPharmaceutical PreparationsReceptors, Dopamine D2Receptors, Opioid, muAdolescenceBrain structureDRD2OPRM1Substance use

Identifiers

PMID34816289
PMCPMC8776605
OpenAlexW3215387976

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.