Evidence map›Paper›PMID 34816264›Full record

ArticlebioRxiv : the preprint server for biology2021

Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro.

Mikhail Ali Hameedi, Erica T Prates, Michael R Garvin, Irimpan Mathews, B Kirtley Amos, Omar Demerdash, Mark Bechthold, Mamta Iyer, Simin Rahighi, Daniel W Kneller and 8 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Mikhail Ali HameediSLAC National Accelerator Laboratory, Stanford Synchrotron Radiation Lightsource, Structural Molecular Biology, Menlo Park, CA 94025, USA.
Erica T PratesBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN.
Michael R GarvinBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN.
Irimpan MathewsSLAC National Accelerator Laboratory, Stanford Synchrotron Radiation Lightsource, Structural Molecular Biology, Menlo Park, CA 94025, USA.
B Kirtley AmosDepartment of Horticulture, University of Kentucky, Lexington, KY.
Omar DemerdashBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN.
Mark BechtholdStanford University, Department of Structural Biology, Stanford, CA 94305, USA.
Mamta IyerChapman University School of Pharmacy, Irvine, CA 92618, USA.
Simin RahighiChapman University School of Pharmacy, Irvine, CA 92618, USA.
Daniel W KnellerNational Virtual Biotechnology Laboratory, US Department of Energy.
Andrey KovalevskyNational Virtual Biotechnology Laboratory, US Department of Energy.
Stephan IrleComputational Sciences and Engineering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA.
Van-Quan VuongThe Bredesen Center for Interdisciplinary Research and Graduate Education, University of Tennessee Knoxville, Knoxville, TN.
Julie C MitchellBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN.
Audrey LabbeBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN.
Stephanie GalanieBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN.
Soichi WakatsukiSLAC National Accelerator Laboratory, Stanford Synchrotron Radiation Lightsource, Structural Molecular Biology, Menlo Park, CA 94025, USA.
Daniel JacobsonBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN.
Oak Ridge National Laboratory · USSLAC National Accelerator Laboratory · USChapman University · USStanford University · USUniversity of Kentucky · USUniversity of Tennessee at Knoxville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In addition to its essential role in viral polyprotein processing, the SARS-CoV-2 3C-like (3CLpro) protease can cleave human immune signaling proteins, like NF-κB Essential Modulator (NEMO) and deregulate the host immune response. Here,

Identifiers

PMID34816264
PMCPMC8609902
OpenAlexW3213829175

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.