Evidence map›Paper›PMID 34816137›Full record

ArticleJVS-vascular science2021

Development of a murine iliac arteriovenous fistula model for examination of hemodialysis access-related limb pathophysiology.

Kyoungrae Kim, Erik M Anderson, Andrew J Martin, Qiongyao Hu, Tomas A Cort, Kenneth C Harland, Kerri A O'Malley, Guanyi Lu, Scott A Berceli, Terence E Ryan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JVS-vascular science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. The rodent models of arteriovenous fistula.Frontiers in cardiovascular medicine · 2024
    Review
  4. American journal of physiology. Renal physiology · 2023
    Article
  5. Article
  6. A Murine Model of Hemodialysis Access-related Hand Dysfunction.Journal of visualized experiments : JoVE · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kyoungrae KimDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Fla.
Erik M AndersonDivision of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Fla.
Andrew J MartinDivision of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Fla.
Qiongyao HuDivision of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Fla.
Tomas A CortDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Fla.
Kenneth C HarlandDivision of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Fla.
Kerri A O'MalleyDivision of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Fla.
Guanyi LuDivision of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Fla.
Scott A BerceliDivision of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Fla.
Terence E RyanDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Fla.
Salvatore T ScaliDivision of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Fla.
University of Florida · USMalcom Randall VA Medical Center · US

Funding

Molecular mechanisms regulating peripheral arterial disease pathobiology in chronic kidney diseaseR01HL149704 · NHLBI · UNIVERSITY OF FLORIDA · PI Terence E Ryan · 2020 to 2026
$3.6M
Impaired Mitochondrial Energetics is a Driver of Hemodialysis Access Related Hand DysfunctionR01HL148597 · NHLBI · UNIVERSITY OF FLORIDA · PI SCALI, SALVATORE T. · 2019 to 2023
$2.7M
Translational and Computational Analysis of Dialysis Fistula Maturation Failure-2R01DK119274 · NIDDK · UNIVERSITY OF FLORIDA · PI BERCELI, SCOTT A · 2019 to 2022
$2.2M
NHLBI NIH HHS R01 HL148597NHLBI NIH HHS R01 HL149704NIDDK NIH HHS R01 DK119274
6 · The paper itself

Abstract

objectiveHemodialysis access-related hand dysfunction is a common clinical feature of patients with chronic kidney disease (CKD) after arteriovenous fistula (AVF) placement. The heterogeneity in symptoms and the lack of a predictive association with changes in hemodynamic alterations precipitated by the AVF suggest that other factors are involved in the mechanisms responsible for causing hand and limb dysfunction postoperatively. To the best of our knowledge, no suitable animal models have provided a platform for performing preclinical experiments designed to elucidate the biologic drivers of access-related hand dysfunction. Therefore, our objective was to develop a novel murine AVF model that could be used to study dialysis access-related limb dysfunction.

methodsMale 8-week-old C57BL/6J mice (n = 15/group) were exposed to either an adenine-supplemented diet to induce CKD or casein-based chow (control). Four weeks after the diet intervention, the mice were randomly assigned to receive an iliac AVF (n = 10/group) or sham surgery (n = 5/group) on the left hindlimb. The mice were sacrificed 2 weeks after surgery, and AVF specimens and hindlimb skeletal muscles were collected for further analysis.

resultsBefore AVF or sham surgery, the glomerular filtration rates were significantly reduced and the blood urea nitrogen levels were significantly elevated in the CKD groups compared with the controls (

conclusionsThe results from the present study have demonstrated that iliac AVF formation is a practical animal model that facilitates examination of hemodialysis access-related limb dysfunction. AVF surgery produced the expected hemodynamic changes, and evaluation of the limb muscle revealed a substantial mitochondrial impairment that was present without changes in muscle size.

Indexed as

Arteriovenous fistulaHand dysfunctionHemodialysisMitochondriaVenous hypertension

Identifiers

PMID34816137
PMCPMC8591416
OpenAlexW3202376158

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.