Evidence map›Paper›PMID 34816112›Full record

ArticleJournal of translational autoimmunity2021

Multiple autoimmunity and epitope spreading in monozygotic twins.

Esperanza Avalos-Díaz, Elena Pérez-Pérez, Julio Granados, Deyanira Pacheco-Tovar, Juan-José Bollain-Y-Goytia-de-la-Rosa, Rafael Herrera-Esparza

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational autoimmunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. The autoimmune tautology revisited.Journal of translational autoimmunity · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Esperanza Avalos-DíazUniversidad Autónoma de Zacatecas, Department of Immunology, UACB. Guadalupe, Zac, Mexico.
Elena Pérez-PérezUniversidad Autónoma de Zacatecas, Department of Immunology, UACB. Guadalupe, Zac, Mexico.
Julio GranadosInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Department of Transplantation, Mexico City, Mexico.
Deyanira Pacheco-TovarUniversidad Autónoma de Zacatecas, Department of Immunology, UACB. Guadalupe, Zac, Mexico.
Juan-José Bollain-Y-Goytia-de-la-RosaUniversidad Autónoma de Zacatecas, Department of Immunology, UACB. Guadalupe, Zac, Mexico.
Rafael Herrera-EsparzaUniversidad Autónoma de Zacatecas, Department of Immunology, UACB. Guadalupe, Zac, Mexico.
Universidad Autónoma de Zacatecas "Francisco García Salinas" · MXInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibodies. A critical review is presented regarding the role of MHC II molecules linked to clinical manifestations of various autoimmune diseases displayed in a single patient, as is the case in the twin patients reported here.

Indexed as

AMA, anti-mitochondrial antibodiesANA, antinuclear antibodiesANCA, antineutrophil cytoplasmic antibodiesAnti-CCP, anti-cyclic citrullinated peptide antibodiesAnti-GBM, anti-glomerular basement membrane antibodiesASMA, anti-smooth muscle antibodiesAutoimmune diseasesAutoimmunityBP, bullous pemphigoidDsg, desmogleinEpitope spreadingFITC, fluorescein isothiocyanateHLA, Human Leucocyte AntigenHRP, horseradish peroxidaseIgG, immunoglobulin GMHC, major histocompatibility complexMultiple autoimmunityPBS, phosphate buffered salineSSP, sequence specific primingThyroiditisTMB, tetramethylbenzidine/H2O2Vitiligo

Identifiers

PMID34816112
PMCPMC8593657
OpenAlexW3213662234

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.