ArticleJGH open : an open access journal of gastroenterology and hepatology2021
Prediction of esophagogastric varices associated with oxaliplatin administration.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 7 citations in OpenAlex.
- Oxaliplatin-related Portal Hypertension Complicated with Esophageal Varices and Refractory Massive Ascites.Internal medicine (Tokyo, Japan) · 2022Article
- Isolated gastric variceal bleeding related to non-cirrhotic portal hypertension following oxaliplatin-based chemotherapy: A case report.World journal of gastroenterology · 2022Article
- Splenomegaly during oxaliplatin-based chemotherapy: impact on blood parameters and anti-neoplastic treatment.Translational cancer research · 2022Article
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Authors and funding
19 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOxaliplatin is a key drug for the chemotherapy of colorectal cancer; however, it is also known to cause non-cirrhotic portal hypertension. We aimed to identify the characteristics of patients who developed esophagogastric varices (EGVs) after treatment with oxaliplatin.
methodsThis study retrospectively analyzed patients with colorectal cancer who were treated with chemotherapy including oxaliplatin between 2010 and 2016. All patients were evaluated by contrast-enhanced computed tomography (CE-CT) every 3 months both during and after treatment; and endoscopy was performed when appearance of portal hypertension was suspected.
resultsA total of 106 patients were divided into two groups: EGV formation (
conclusionsEGV formation could be predicted by the assessment of platelet counts and spleen size. If progressive splenomegaly and thrombocytopenia are observed not only during but also after completion of the oxaliplatin-containing chemotherapy, EGVs should be confirmed by endoscopy for avoiding subsequent rupture.
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