Evidence map›Paper›PMID 34815809›Full record

ReviewTheranostics2021

Recent progress and new challenges in modeling of human pluripotent stem cell-derived blood-brain barrier.

Li Yan, Rebecca A Moriarty, Kimberly M Stroka

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Review
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  3. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Li YanFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Rebecca A MoriartyFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Kimberly M StrokaFischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The blood-brain barrier (BBB) is a semipermeable unit that serves to vascularize the central nervous system (CNS) while tightly regulating the movement of molecules, ions, and cells between the blood and the brain. The BBB precisely controls brain homeostasis and protects the neural tissue from toxins and pathogens. The BBB is coordinated by a tight monolayer of brain microvascular endothelial cells, which is subsequently supported by mural cells, astrocytes, and surrounding neuronal cells that regulate the barrier function with a series of specialized properties. Dysfunction of barrier properties is an important pathological feature in the progression of various neurological diseases.

Indexed as

AstrocytesBiological TransportBlood-Brain BarrierBrainCell DifferentiationCentral Nervous SystemEndothelial CellsHumansInduced Pluripotent Stem CellsModels, BiologicalNeuronsPericytesPluripotent Stem Cellsblood-brain barrierbrain microvascular endothelial cellsdisease modeling.neurovascular unitpluripotent stem cells

Identifiers

PMID34815809
PMCPMC8581424

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.