Evidence map›Paper›PMID 34815805›Full record

ArticleTheranostics2021

Sult2b1 deficiency exacerbates ischemic stroke by promoting pro-inflammatory macrophage polarization in mice.

Yan Wang, Haojie Jin, Yafang Wang, Yang Yao, Cuixia Yang, Jihong Meng, Xiaomu Tan, Yu Nie, Lixiang Xue, Baohui Xu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. The Microbiome Modulates Corneal Wound Healing via the Induction of Cholesterol Sulfotransferase Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. MacrophageLife science alliance · 2023
    Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Yan WangDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, USA.
Haojie JinThe College of Forestry, Beijing Forestry University, Beijing, China.
Yafang WangShanghai Institute of Immunology, Translational Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yang YaoDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, USA.
Cuixia YangResearch Center of Translational Medicine, Shanghai Children's hospital, State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jihong MengDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, USA.
Xiaomu TanDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, USA.
Yu NieFuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China.
Lixiang XueInstitute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China.
Baohui XuDivision of Vascular Surgery, Department of Surgery, Stanford University School of Medicine, 1201Welch Road, MSLS Building, Stanford, USA.
Heng ZhaoDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, USA.
Feng WangShanghai Institute of Immunology, Translational Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Stanford University · USPeking University · CNBeijing Forestry University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNShanghai First People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBrain IschemiaCholesterol EstersDisease Models, AnimalHumansInfarction, Middle Cerebral ArteryInflammationIschemic StrokeMacrophage ActivationMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMicrogliaMonocytesCholesterol Esterscholesteryl sulfateSulfotransferasesSULT2B1 protein, humanCholesterol SulfateIschemic StrokeMacrophageNeuroinflammationSult2b1

Identifiers

PMID34815805
PMCPMC8581421
OpenAlexW3213805778

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.