Evidence map›Paper›PMID 34815797›Full record

ArticleTheranostics2021

BPI overexpression suppresses Treg differentiation and induces exosome-mediated inflammation in systemic lupus erythematosus.

Huai-Chia Chuang, Ming-Han Chen, Yi-Ming Chen, Huang-Yu Yang, Yi-Ru Ciou, Chia-Hsin Hsueh, Ching-Yi Tsai, Tse-Hua Tan

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Regulatory T cells in cancer and inflammation.Signal transduction and targeted therapy · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Exosomes as immunomodulators in autoimmune inflammation: implications for primary Sjögren's disease.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Exosome-Based Therapeutics in Dermatology.Biomaterials research · 2025
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Huai-Chia ChuangImmunology Research Center, National Health Research Institutes, Zhunan, Taiwan.
Ming-Han ChenDivision of Allergy, Immunology, and Rheumatology, Taipei Veterans General Hospital, Taipei, Taiwan.
Yi-Ming ChenDivision of Allergy, Immunology, and Rheumatology, Taichung Veterans General Hospital, Taichung, Taiwan.
Huang-Yu YangDepartment of Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Yi-Ru CiouImmunology Research Center, National Health Research Institutes, Zhunan, Taiwan.
Chia-Hsin HsuehImmunology Research Center, National Health Research Institutes, Zhunan, Taiwan.
Ching-Yi TsaiImmunology Research Center, National Health Research Institutes, Zhunan, Taiwan.
Tse-Hua TanImmunology Research Center, National Health Research Institutes, Zhunan, Taiwan.
National Health Research Institutes · TWBaylor College of Medicine · USChang Gung Memorial Hospital · TWTaichung Veterans General Hospital · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAnimalsAntimicrobial Cationic PeptidesBlood ProteinsCell DifferentiationExosomesFemaleGene ExpressionGene Expression RegulationHumansInflammation MediatorsLupus Erythematosus, SystemicLymphocyte ActivationMaleMiceAntimicrobial Cationic Peptidesbactericidal permeability increasing proteinBlood ProteinsInflammation MediatorsBPIexosomesSLET cellsTreg

Identifiers

PMID34815797
PMCPMC8581436
OpenAlexW3208916044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.