Evidence map›Paper›PMID 34815793›Full record

ArticleTheranostics2021

Establishment of tumor inflammasome clusters with distinct immunogenomic landscape aids immunotherapy.

Qingyu Liang, Jianqi Wu, Xin Zhao, Shuai Shen, Chen Zhu, Tianqi Liu, Xiao Cui, Ling Chen, Chunmi Wei, Peng Cheng and 2 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Interaction of HIF-1a with various cell death pathways in tumor immune microenvironment (TIME).Apoptosis : an international journal on programmed cell death · 2026
    Pooled it
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  8. Nanoparticles for cancer therapy: a review of influencing factors and evaluation methods for biosafety.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Qingyu LiangDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, China.
Jianqi WuDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, China.
Xin ZhaoDepartment of Basic Medicine, China Medical University, Shenyang, China.
Shuai ShenDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, China.
Chen ZhuDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, China.
Tianqi LiuDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, China.
Xiao CuiDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, China.
Ling ChenDepartment of Neurosurgery, Chinese People's Liberation Army of China (PLA) General Hospital, Medical School of Chinese PLA, Institute of Neurosurgery of Chinese PLA, China.
Chunmi WeiDepartment of Radiotherapy, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China.
Peng ChengDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, China.
Wen ChengDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, China.
Anhua WuDepartment of Neurosurgery, The First Hospital of China Medical University, Shenyang, China.
First Hospital of China Medical University · CNChina Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammasome signaling is a reaction cascade that influences immune response and cell death. Although the inflammasomes participate in tumorigenesis, their role as an oncogenic booster or a tumor suppresser is still controversial. Therefore, it is important to comprehensively investigate the inflammasome signaling status across various cancers to clarify its clinical and therapeutic significance.

Indexed as

Biomarkers, TumorCarcinogenesisChinaDatabases, GeneticGene ExpressionGene Expression ProfilingGene Expression Regulation, NeoplasticGenes, Tumor SuppressorHumansImmunologic FactorsImmunotherapyInflammasomesNeoplasmsPrognosisSignal TransductionTranscriptomeBiomarkers, TumorImmunologic FactorsInflammasomesimmunotherapyInflammasomeprognosistumor-associated macrophagestumor classification

Identifiers

PMID34815793
PMCPMC8581407
OpenAlexW3209523250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.