Evidence map›Paper›PMID 34815790›Full record

ArticleTheranostics2021

Multiple regression analysis of a comprehensive transcriptomic data assembly elucidates mechanically- and biochemically-driven responses to focused ultrasound blood-brain barrier disruption.

Alexander S Mathew, Catherine M Gorick, Richard J Price

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  11. Ultrasound-targeted nucleic acid delivery for solid tumor therapy.Journal of controlled release : official journal of the Controlled Release Society · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alexander S MathewDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA.
Catherine M GorickDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA.
Richard J PriceDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA.
University of Virginia · US

Funding

Innovative systemic gene therapy for treating Parkinson's diseaseR01NS111102 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI PRICE, RICHARD J., SUK, JUNG SOO · 2019 to 2023
$2.6M
Targeted Delivery of Brain Penetrating DNA Nanoparticles to Brain TumorsR01CA204968 · NCI · JOHNS HOPKINS UNIVERSITY · PI HANES, JUSTIN S., SUK, JUNG SOO · 2016 to 2020
$2.5M
Genome Editing the Blood-Brain Barrier with Sonoselective Focused UltrasoundR01EB030744 · NIBIB · UNIVERSITY OF VIRGINIA · PI PRICE, RICHARD J. · 2021 to 2024
$2.4M
Focused ultrasound pre-conditioning for augmented nanoparticle penetration in infiltrative gliomasR01EB030409 · NIBIB · UNIVERSITY OF VIRGINIA · PI HANES, JUSTIN S., PRICE, RICHARD J. · 2021 to 2024
$2.3M
ImmunoPET Assessment of anti-CD47 Immunotherapy Delivery to Glioblastoma with Focused UltrasoundR21NS118278 · NINDS · UNIVERSITY OF VIRGINIA · PI PRICE, RICHARD J. · 2020 to 2020
$420k
Leveraging Focused Ultrasound to Sensitize Refractory Melanoma to ImmunotherapyF30CA247254 · NCI · UNIVERSITY OF VIRGINIA · PI MATHEW, ALEXANDER SEAN · 2020 to 2022
$138k
NCI NIH HHS F30 CA247254NCI NIH HHS R01 CA204968NIBIB NIH HHS R01 EB030409NIBIB NIH HHS R01 EB030744NINDS NIH HHS R01 NS111102NINDS NIH HHS R21 NS118278
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBiomechanical PhenomenaBlood-Brain BarrierBrainContrast MediaDatabases, GeneticDrug Delivery SystemsGene ExpressionMiceMicrobubblesMultivariate AnalysisRegression AnalysisTranscriptomeUltrasonic TherapyContrast Mediablood-brain barrierdrug deliveryfocused ultrasoundneurogenesistranscriptomics

Identifiers

PMID34815790
PMCPMC8581408
OpenAlexW3210243069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.