Evidence map›Paper›PMID 34815665›Full record

ArticleDrug design, development and therapy2021

Antifungal Effects and Potential Mechanisms of Benserazide Hydrochloride Alone and in Combination with Fluconazole Against

Xueqi Chen, Jiyong Wu, Lei Sun, Jing Nie, Shan Su, Shujuan Sun

Open access · goldAbstract read
In one paragraph

Article in Drug design, development and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. A Cecropin-4 Derived Peptide C18 InhibitsFrontiers in microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xueqi ChenDepartment of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, People's Republic of China.
Jiyong WuDepartment of Pharmacy, Shandong Second Provincial General Hospital, Jinan, People's Republic of China.
Lei SunDepartment of Pharmacy, Shandong Second Provincial General Hospital, Jinan, People's Republic of China.
Jing NieDepartment of Pharmacy, Shandong Second Provincial General Hospital, Jinan, People's Republic of China.
Shan SuDepartment of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, People's Republic of China.
Shujuan SunDepartment of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development, Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Jinan, People's Republic of China.ORCID 0000-0002-9141-9717
China-Japan Friendship Hospital · CNShandong Provincial QianFoShan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe resistance of MATERIALS AND

methodsIn vitro antifungal effects were performed by broth microdilution assay and XTT reduction assay. Infected

resultsBEH alone exhibited obvious antifungal activities against

conclusionBEH alone or combined with FLC displayed potent antifungal activity both in vitro and in vivo, and the underlying mechanisms were related to reduced virulence factors.

Indexed as

AnimalsAntifungal AgentsBenserazideBiofilmsCandida albicansDose-Response Relationship, DrugDrug Resistance, FungalDrug Therapy, CombinationFluconazoleMicrobial Sensitivity TestsMothsAntifungal AgentsBenserazideFluconazolebenserazidebiofilmfluconazolefluconazole-resistant Candida albicansGalleria mellonellasynergism

Identifiers

PMID34815665
PMCPMC8605804
OpenAlexW3212893883

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.