Evidence map›Paper›PMID 34815583›Full record

ArticleCollection of Czechoslovak chemical communications2006

NUCLEOSIDE PRODRUGS OF A

Pedro Besada, Liaman K Mamedova, Krishnan K Palaniappan, Zhan-Guo Gao, Bhalchandra V Joshi, Lak Shin Jeong, Mortimer M Civan, Kenneth A Jacobson

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Collection of Czechoslovak chemical communications, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06236555 (Exploring 8-iso Prostaglandin F2α and Adenosine Deaminase Levels in Periodontal Health and Disease), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06236555 nacompletednot on this mapstarted 2023, after this paper: background citation

Exploring 8-iso Prostaglandin F2α and Adenosine Deaminase Levels in Periodontal Health and Disease

TypeinterventionalSponsorEda Cetin OzdemirRan2023 to 2024Enrolled80ConditionsPeriodontal DiseasesArms8-iso Prostaglandin F2α and Adenosine Deaminase
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Adenosine receptors as promising targets for the management of ocular diseases.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2021
    Review
  4. Design and in vivo activity of APurinergic signalling · 2020
    Article
  5. Ocular Purine Receptors as Drug Targets in the Eye.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2016
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Pedro BesadaMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0810, U.S.A.
Liaman K MamedovaMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0810, U.S.A.
Krishnan K PalaniappanMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0810, U.S.A.
Zhan-Guo GaoMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0810, U.S.A.
Bhalchandra V JoshiMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0810, U.S.A.
Lak Shin JeongLaboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul 120-750, Korea.
Mortimer M CivanDepartments of Physiology and Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A.
Kenneth A JacobsonMolecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0810, U.S.A.
Ewha Womans University · KR

Funding

Aqueous Humor Outflow Control and Intraocular PressureR01EY013624 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CIVAN, MORTIMER MORDECAI · 2001 to 2013
$5.6M
Drugs that Act at Adenosine ReceptorsZ01DK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 1991 to 2008
$854k
Intramural NIH HHS Z01 DK031117NEI NIH HHS R01 EY013624
6 · The paper itself

Abstract

9-(β-D-Ribosfuranosyluronamide)adenine derivatives that are selective agonists and antagonists of the A

Indexed as

Adenosine receptorsAdenylate cyclaseG protein-coupled receptorsNucleosidesProdrugsPurinesReceptor binding assays

Identifiers

PMID34815583
PMCPMC8608517
OpenAlexW2033188222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.