ArticleScientific reports2021
Human intracranial recordings reveal distinct cortical activity patterns during invasive and non-invasive vagus nerve stimulation.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- The effects of transcutaneous vagus nerve stimulation on romantic couples' physiology and behavior during conflict.Anxiety, stress, and coping · 2026Trial
- Stereo-electroencephalography-guided radiofrequency thermocoagulation in patients with implanted neuromodulation devices: patient series.Journal of neurosurgery. Case lessons · 2026Article
- A Protocol to Acquire Infant Heart Rate Variability in the Rohingya Camps and Surrounding Communities in Cox's Bazar, Bangladesh.Psychophysiology · 2026Article
- Differential Gamma Responses to Transcutaneous Auricular Vagus Nerve Stimulation Revealed by Human Intracranial Recordings.Neuromodulation : journal of the International Neuromodulation Society · 2026Article
- Vagus nerve stimulation: a potential tool to further improve perioperative anesthesia management quality and postoperative recovery?Frontiers in medicine · 2026Review
- Article
- Effects of stimulation site and protocol on autonomic responses to auricular vagus nerve stimulation.Frontiers in neuroscience · 2025Article
- Vagus nerve stimulation as a predictive coding modulator that enhances feedforward over feedback transmission.Frontiers in neural circuits · 2025Review
- Vibrotactile auricular vagus nerve stimulation alters limbic system connectivity in humans: A pilot study.PloS one · 2025Article
- Neurotechnology for enhancing human operation of robotic and semi-autonomous systems.Frontiers in robotics and AI · 2025Review
- Therapeutic observation of transcutaneous auricular vagus nerve stimulation for chronic migraine in pediatric patients: a case report.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Label-Free Functional Imaging of Vagus Nerve Stimulation-Evoked Potentials at the Cortical Surface.Research square · 2024Article
- Label-free functional imaging of vagus nerve stimulation-evoked potentials at the cortical surface.Npj biosensing · 2024Article
- Transcutaneous Auricular Vagus Nerve Stimulation Modulates Performance but Not Pupil Size During Nonnative Speech Category Learning.Journal of speech, language, and hearing research : JSLHR · 2023Article
- Neuropsychiatric Lyme Disease and Vagus Nerve Stimulation.Antibiotics (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Vagus nerve stimulation (VNS) is being used increasingly to treat a wide array of diseases and disorders. This growth is driven in part by the putative ability to stimulate the nerve non-invasively. Despite decades of use and a rapidly expanding application space, we lack a complete understanding of the acute effects of VNS on human cortical neurophysiology. Here, we investigated cortical responses to sub-perceptual threshold cervical implanted (iVNS) and transcutaneous auricular (taVNS) vagus nerve stimulation using intracranial neurophysiological recordings in human epilepsy patients. To understand the areas that are modulated by VNS and how they differ depending on invasiveness and stimulation parameters, we compared VNS-evoked neural activity across a range of stimulation modalities, frequencies, and amplitudes. Using comparable stimulation parameters, both iVNS and taVNS caused subtle changes in low-frequency power across broad cortical networks, which were not the same across modalities and were highly variable across participants. However, within at least some individuals, it may be possible to elicit similar responses across modalities using distinct sets of stimulation parameters. These results demonstrate that both invasive and non-invasive VNS cause evoked changes in activity across a set of highly distributed cortical networks that are relevant to a diverse array of clinical, rehabilitative, and enhancement applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.