Evidence map›Paper›PMID 34815515›Full record

ArticleCommunications biology2021

Vibrational spectroscopy analysis of ligand efficacy in human M

Kota Katayama, Kohei Suzuki, Ryoji Suno, Ryoji Kise, Hirokazu Tsujimoto, So Iwata, Asuka Inoue, Takuya Kobayashi, Hideki Kandori

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Discovering Key Activation Hotspots in the MJournal of the American Chemical Society · 2025
    Article
  3. Holistic concepts in GPCR dynamics.Biophysics and physicobiology · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Kota Katayama *Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, 466-8555, Japan. Katayama.kota@nitech.ac.jp.ORCID http://orcid.org/0000-0001-8498-4374
Kohei Suzuki *Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, 466-8555, Japan.
Ryoji SunoDepartment of Medical Chemistry, Kansai Medical University, Hirakata, 573-1010, Japan.
Ryoji KiseGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan.
Hirokazu TsujimotoDepartment of Cell Biology and Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
So IwataDepartment of Cell Biology and Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan.
Asuka InoueGraduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, 980-8578, Japan.ORCID http://orcid.org/0000-0003-0805-4049
Takuya KobayashiDepartment of Medical Chemistry, Kansai Medical University, Hirakata, 573-1010, Japan.
Hideki KandoriDepartment of Life Science and Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya, 466-8555, Japan. kandori@nitech.ac.jp.ORCID http://orcid.org/0000-0002-4922-1344
Nagoya Institute of Technology · JPKansai Medical University · JPKyoto University · JPTohoku University · JP

Funding

MEXT | Japan Science and Technology Agency (JST) JPMJPR19G4MEXT | Japan Society for the Promotion of Science (JSPS) 18K14662
6 · The paper itself

Abstract

The intrinsic efficacy of ligand binding to G protein-coupled receptors (GPCRs) reflects the ability of the ligand to differentially activate its receptor to cause a physiological effect. Here we use attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy to examine the ligand-dependent conformational changes in the human M

Indexed as

HumansLigandsReceptor, Muscarinic M2Spectrum AnalysisCHRM2 protein, humanLigandsReceptor, Muscarinic M2

Identifiers

PMID34815515
PMCPMC8635417
OpenAlexW3214896056

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.