Evidence map›Paper›PMID 34815495›Full record

Observational studyScientific reports2021

Reduction in femoral neck and total hip bone mineral density following hospitalisation for diabetes-related foot ulceration.

Marcel M Nejatian, Salar Sobhi, Blake N Sanchez, Kathryn Linn, Laurens Manning, Shuen-Chyn Soh, Jonathan Hiew, J Carsten Ritter, Bu B Yeap, Emma J Hamilton

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Review
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Marcel M Nejatian *Medical School, The University of Western Australia, Perth, Australia.
Salar Sobhi *Medical School, The University of Western Australia, Perth, Australia.
Blake N Sanchez *Medical School, The University of Western Australia, Perth, Australia.
Kathryn LinnDepartment of Nuclear Medicine, Fiona Stanley Hospital, Perth, Australia.
Laurens ManningMedical School, The University of Western Australia, Perth, Australia.
Shuen-Chyn SohMedical School, The University of Western Australia, Perth, Australia.
Jonathan HiewMultidisciplinary Diabetes Foot Unit, Fiona Stanley Hospital, Perth, Australia.
J Carsten RitterMultidisciplinary Diabetes Foot Unit, Fiona Stanley Hospital, Perth, Australia.
Bu B YeapMedical School, The University of Western Australia, Perth, Australia.
Emma J HamiltonMedical School, The University of Western Australia, Perth, Australia. emma.hamilton@health.wa.gov.au.
University of Western Australia · AUFiona Stanley Hospital · AUCurtin University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Management of diabetes-related foot ulceration (DFU) includes pressure offloading resulting in a period of reduced activity. The metabolic effects of this are unknown. This study aims to investigate changes in bone mineral density (BMD) and body composition 12 weeks after hospitalisation for DFU. A longitudinal, prospective, observational study of 22 people hospitalised for DFU was conducted. Total body, lumbar spine, hip and forearm BMD, and total lean and fat mass were measured by dual-energy X-ray absorptiometry (DXA) during and 12 weeks after hospitalisation for DFU. Significant losses in total hip BMD of the ipsilateral limb (- 1.7%, p < 0.001), total hip BMD of the contralateral limb (- 1.4%, p = 0.005), femoral neck BMD of the ipsilateral limb (- 2.8%, p < 0.001) and femoral neck BMD of the contralateral limb (- 2.2%, p = 0.008) were observed after 12 weeks. Lumbar spine and forearm BMD were unchanged. HbA1c improved from 75 mmol/mol (9.2%) to 64 mmol/mol (8.0%) (p = 0.002). No significant changes to lean and fat mass were demonstrated. Total hip and femoral neck BMD decreased bilaterally 12 weeks after hospitalisation for DFU. Future research is required to confirm the persistence and clinical implications of these losses.

Indexed as

Bone DensityAustraliaBody CompositionDiabetes MellitusDiabetic FootFemaleFemur NeckHospitalizationHumansLumbar VertebraeMaleMiddle AgedOsteoporosisProspective Studies

Identifiers

PMID34815495
PMCPMC8611081
OpenAlexW3215988420

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.