Evidence map›Paper›PMID 34815449›Full record

ArticleScientific reports2021

Nanovibrational stimulation inhibits osteoclastogenesis and enhances osteogenesis in co-cultures.

Ian W Kennedy, P Monica Tsimbouri, Paul Campsie, Shatakshi Sood, Peter G Childs, Stuart Reid, Peter S Young, Dominic R M Meek, Carl S Goodyear, Matthew J Dalby

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Mechanical Phenotyping of MG63s Following Vibrational Stimulation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Ian W KennedyCentre for the Cellular Microenvironment, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK. ian.kennedy4@nhs.scot.
P Monica TsimbouriCentre for the Cellular Microenvironment, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Paul CampsieSUPA Department of Biomedical Engineering, University of Strathclyde, Glasgow, G1 1QE, UK.
Shatakshi SoodInstitute of Infection, Immunity and Inflammation, Glasgow Biomedical Research Centre, University Place, University of Glasgow, Glasgow, G12 8TA, UK.
Peter G ChildsSUPA Department of Biomedical Engineering, University of Strathclyde, Glasgow, G1 1QE, UK.
Stuart ReidSUPA Department of Biomedical Engineering, University of Strathclyde, Glasgow, G1 1QE, UK.
Peter S YoungCentre for the Cellular Microenvironment, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Dominic R M MeekDepartment of Trauma and Orthopaedics, Queen Elizabeth University Hospital, Glasgow, G51 4TF, UK.
Carl S GoodyearInstitute of Infection, Immunity and Inflammation, Glasgow Biomedical Research Centre, University Place, University of Glasgow, Glasgow, G12 8TA, UK.
Matthew J DalbyCentre for the Cellular Microenvironment, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
University of Glasgow · GBUniversity of Strathclyde · GBQueen Elizabeth University Hospital · GB

Funding

Engineering and Physical Sciences Research Council EP/N013905/1Royal College of Surgeons of Edinburgh SRG/17/113
6 · The paper itself

Abstract

Models of bone remodelling could be useful in drug discovery, particularly if the model is one that replicates bone regeneration with reduction in osteoclast activity. Here we use nanovibrational stimulation to achieve this in a 3D co-culture of primary human osteoprogenitor and osteoclast progenitor cells. We show that 1000 Hz frequency, 40 nm amplitude vibration reduces osteoclast formation and activity in human mononuclear CD14

Indexed as

Cell DifferentiationOsteogenesisVibrationBone Marrow CellsCoculture TechniquesHumansNanotechnologyOsteoclasts

Identifiers

PMID34815449
PMCPMC8611084
OpenAlexW3217452968

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.