ArticleNature communications2021
Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- Evolutionary convergence and niche-specific regulation of core HIF1A pathway genes synergistically drive divergent hypoxia adaptation in mammals.BMC ecology and evolution · 2026Article
- Comparative analysis of naked mole-rat thermogenesis and its potential to maintain euthermia in response to cold.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- IGF-mediated glucose signalling is retained in adult naked mole-rats.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Review
- Naked mole-rats employ a normoxic escape behaviour that is altered by social interaction.Biology letters · 2025Article
- Natural Mutation in Naked Mole-Rat UCP1 Refutes Importance of the Histidine Pair Motif for Proton Conductance and Thermogenesis.Acta physiologica (Oxford, England) · 2025Article
- Severe acute hypoxia upregulates anaerobic metabolism in non-reproductive but not queen naked mole-rats.The Journal of experimental biology · 2025Article
- Brown adipose tissue: a potential target for aging interventions and healthy longevity.Biogerontology · 2024Review
- Enhanced mitochondrial buffering prevents CaThe Journal of physiology · 2024Article
- Gene expression and metabolite levels converge in the thermogenic spadix of skunk cabbage.Plant physiology · 2024Article
- Hypoxia impairs blood glucose homeostasis in naked mole-rat adult subordinates but not queens.The Journal of experimental biology · 2024Article
- Hypothalamic Neuromodulation of Hypothermia in Domestic Animals.Animals : an open access journal from MDPI · 2024Review
- Hypoxic and hypercapnic burrow conditions lead to downregulation of free triiodothyronine and hematocrit in Ansell's mole-rats (Fukomys anselli).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- The glutamatergic drive to breathe is reduced in severe but not moderate hypoxia in Damaraland mole-rats.The Journal of experimental biology · 2023Article
- Adenosine and γ-aminobutyric acid partially regulate metabolic and ventilatory responses of Damaraland mole-rats to acute hypoxia.The Journal of experimental biology · 2023Article
- Cellular senescence induction leads to progressive cell death via the INK4a-RB pathway in naked mole-rats.The EMBO journal · 2023Article
- Proline hydroxylase 2 (PHD2) promotes brown adipose thermogenesis by enhancing the hydroxylation of UCP1.Molecular metabolism · 2023Article
- The Role of Brown Adipose Tissue and Energy Metabolism in Mammalian Thermoregulation during the Perinatal Period.Animals : an open access journal from MDPI · 2023Review
- Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism.Cell metabolism · 2023Article
- Metabolism, homeostasis, and aging.Trends in endocrinology and metabolism: TEM · 2023Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Naked mole-rats are among the most hypoxia-tolerant mammals. During hypoxia, their body temperature (T
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.