Evidence map›Paper›PMID 34815356›Full record

ArticleJournal for immunotherapy of cancer2021

Pan-cancer landscape of

Andrew D Kelly, Karthikeyan Murugesan, Zheng Kuang, Meagan Montesion, Jeffrey S Ross, Lee A Albacker, Richard S P Huang, Douglas I Lin, Umut Demirci, James Creeden

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal for immunotherapy of cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  8. Circulating Tumor DNA Enables Sensitive Detection of Actionable Gene Fusions and Rearrangements Across Cancer Types.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  9. EJHaem · 2023
    Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Andrew D Kelly *Department of Medical Oncology, Foundation Medicine Inc, Cambridge, Massachusetts, USA akelly@foundationmedicine.com.ORCID 0000-0002-5338-7689
Karthikeyan Murugesan *Department of Medical Oncology, Foundation Medicine Inc, Cambridge, Massachusetts, USA.ORCID 0000-0002-2275-1126
Zheng KuangDepartment of Medical Oncology, Foundation Medicine Inc, Cambridge, Massachusetts, USA.
Meagan MontesionDepartment of Medical Oncology, Foundation Medicine Inc, Cambridge, Massachusetts, USA.
Jeffrey S RossDepartment of Medical Oncology, Foundation Medicine Inc, Cambridge, Massachusetts, USA.
Lee A AlbackerDepartment of Medical Oncology, Foundation Medicine Inc, Cambridge, Massachusetts, USA.
Richard S P HuangDepartment of Medical Oncology, Foundation Medicine Inc, Cambridge, Massachusetts, USA.ORCID 0000-0001-8395-5168
Douglas I LinDepartment of Medical Oncology, Foundation Medicine Inc, Cambridge, Massachusetts, USA.
Umut DemirciDepartment of Medical Oncology, Memorial Ankara Hospital, Ankara, Turkey.
James CreedenDepartment of Medical Oncology, Foundation Medicine Inc, Cambridge, Massachusetts, USA.
The Medical Foundation · USMemorial Ankara Hospital · TRSUNY Upstate Medical University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmune checkpoint inhibitors (ICIs) benefit patients with multiple cancer types, however, additional predictive biomarkers of response are needed.

methodsWe analyzed 283,050 patient samples across multiple tumor types that underwent comprehensive genomic profiling for activating

resultsWe identified 145 samples with functional rearrangements in

conclusions

Indexed as

AdultB7-H1 AntigenFemaleHumansImmunotherapyNeoplasmsB7-H1 AntigenCD274 protein, humanbiomarkersimmune toleranceimmunotherapyprogrammed cell death 1 receptortumor

Identifiers

PMID34815356
PMCPMC8611421
OpenAlexW3217354986

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.