Evidence map›Paper›PMID 34815345›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Molecular structure of an open human K

Chen Zhao, Roderick MacKinnon

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Molecular mechanisms of Kir channel gating.Biochemical Society transactions · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Inhibition Mechanism of Pancreatic KResearch (Washington, D.C.) · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Bayliss-Starling Prize Lecture: KThe Journal of physiology · 2025
    Article
  13. Article
  14. Andrology · 2025
    Review
  15. Functional Characterization of Ion Channels in Planar Lipid Bilayers.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  16. Dynamic duo: Kir6 and SUR in KChannels (Austin, Tex.) · 2024
    Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chen ZhaoHHMI, The Rockefeller University, New York, NY 10065.ORCID 0000-0002-2323-6951
Roderick MacKinnonHHMI, The Rockefeller University, New York, NY 10065; mackinn@rockefeller.edu.

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

K

Indexed as

Adenosine DiphosphateAdenosine TriphosphateAllosteric SiteAnimalsBinding SitesCell LineCryoelectron MicroscopyCytoplasmHEK293 CellsHumansInsectaKcnj11 ChannelLipid BilayersModels, MolecularMolecular StructureMutationABCC8 protein, humanAdenosine DiphosphateAdenosine TriphosphateKcnj11 ChannelLipid BilayersPotassiumPotassium ChannelsPotassium Channels, Inwardly RectifyingSulfonylurea ReceptorsATP-sensitive potassium channelion channelKATP

Identifiers

PMID34815345
PMCPMC8640745

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.