Evidence map›Paper›PMID 34815297›Full record

ArticleeNeuro

Three Water Restriction Schedules Used in Rodent Behavioral Tasks Transiently Impair Growth and Differentially Evoke a Stress Hormone Response without Causing Dehydration.

Dmitrii Vasilev, Daniel Havel, Simone Liebscher, Silvia Slesiona-Kuenzel, Nikos K Logothetis, Katja Schenke-Layland, Nelson K Totah

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 4 countries.

Dmitrii VasilevHelsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki 00790, Finland.
Daniel HavelDepartment of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen 72076, Germany.
Simone LiebscherInstitute of Biomedical Engineering, Department for Medical Technologies and Regenerative Medicine, Eberhard Karls University Tübingen, Tübingen 72074, Germany.
Silvia Slesiona-KuenzelDepartment of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen 72076, Germany.
Nikos K LogothetisDepartment of Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Tübingen 72076, Germany.
Katja Schenke-LaylandInstitute of Biomedical Engineering, Department for Medical Technologies and Regenerative Medicine, Eberhard Karls University Tübingen, Tübingen 72074, Germany.
Nelson K TotahHelsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki 00790, Finland nelson.totah@helsinki.fi.ORCID 0000-0002-0998-9770
University of Helsinki · FIGoethe University Frankfurt · DEMax Planck Institute for Biological Cybernetics · DEUniversity of California, Los Angeles · USUniversity of Manchester · GBUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Water restriction is commonly used to motivate rodents to perform behavioral tasks; however, its effects on hydration and stress hormone levels are unknown. Here, we report daily body weight and bi-weekly packed red blood cell volume and corticosterone (CORT) in adult male rats across 80 days for three commonly used water restriction schedules. We also assessed renal adaptation to water restriction using postmortem histologic evaluation of renal medulla. A control group received

Indexed as

DehydrationRodentiaAnimalsBehavior, AnimalCorticosteroneMaleRatsWaterCorticosteroneWater

Identifiers

PMID34815297
PMCPMC8672445
OpenAlexW3215720710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.