Evidence map›Paper›PMID 34815286›Full record

ArticleBMJ open2021

Seroprevalence of anti-SARS-CoV-2 antibodies after the first wave of the COVID-19 pandemic in a vulnerable population in France: a cross-sectional study.

Adeline Beaumont, Cécile Durand, Martine Ledrans, Valérie Schwoebel, Harold Noel, Yann Le Strat, Donatien Diulius, Léa Colombain, Marie Médus, Philippe Gueudet and 2 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Adeline BeaumontSanté publique France, Direction des régions, Occitanie, Toulouse, France.ORCID 0000-0001-7466-2160
Cécile DurandSanté publique France, Direction des régions, Occitanie, Toulouse, France.
Martine LedransSanté publique France, Direction des régions, Occitanie, Toulouse, France.
Valérie SchwoebelSanté publique France, Direction des régions, Occitanie, Toulouse, France.
Harold NoelSanté publique France, Direction des maladies infectieuses, Saint-Maurice, France.
Yann Le StratSanté publique France, Direction appui traitements et analyses des données, Saint-Maurice, France.
Donatien DiuliusAgence régionale de Santé Occitanie, délégation départementale Pyrénées Orientales, Perpignan, France.
Léa ColombainInfectious and Tropical Diseases Department, Perpignan Hospital Center, Perpignan, France.
Marie MédusInfectious and Tropical Diseases Department, Perpignan Hospital Center, Perpignan, France.
Philippe GueudetLaboratory of Biochemistry and Biology, Perpignan Hospital Center, Perpignan, France.
Damien MoulySanté publique France, Direction des régions, Occitanie, Toulouse, France damien.mouly@santepubliquefrance.fr.
Hugues AumaîtreInfectious and Tropical Diseases Department, Perpignan Hospital Center, Perpignan, France.
Santé Publique France · FRCentre Hospitalier de Perpignan · FRAgence Régionale de Santé Ile-de-France · FRLaboratoire de Biochimie · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to assess the level of prior SARS-CoV-2 infection in socially deprived neighbourhoods after the first wave of the pandemic, and to identify factors associated with seropositivity.

designA cross-sectional study.

settingThree socially deprived neighbourhoods of the city of Perpignan, in the south of France, where large settled Roma communities live.

participantsPeople aged 6 years old or over, living in the study area. 700 people were included in the study using two-stage stratified sampling design.

interventionsThe study included a questionnaire and SARS-CoV-2 antibody testing by the Roche Elecsys immunoassay between 29 June and 17 July 2020. PRIMARY AND SECONDARY OUTCOME MEASURES: SARS-CoV-2 antibody seroprevalence was estimated from weighted data. Associated factors and reported symptoms were investigated using univariable and multivariable logistic regressions.

resultsThe seroprevalence of anti-SARS-CoV-2 antibodies was 35.4% (95% CI 30.2% to 41.0%). People aged 15-64 years old had increased odds of being seropositive than those aged 65 years or over. Obese people had higher odds of being seropositive (adjusted OR (aOR)=2.0, 95% CI 1.1 to 3.8). The odds of being seropositive were higher in households with clinical COVID-19 cases (one case: aOR=2.5, 95% CI 1.3 to 5.0; several cases: aOR=6.9, 95% CI 3.1 to 15.2). In the neighbourhood with the highest measured seroprevalence, people living in a dwelling with one to two rooms had higher odds of being seropositive than those living in a four-room house (aOR=2.8, 95% CI 1.2 to 6.3). Working during the lockdown was associated with lower odds of being seropositive (aOR=0.2, 95% CI 0.03 to 1.0).

conclusionTransmission of SARS-COV-2 in this vulnerable population was very high during the COVID-19 pandemic's first wave. Our results highlight the need to strengthen and adapt preventive measures taking into account all social determinants of health, especially housing conditions.

Indexed as

COVID-19AdolescentAdultAntibodies, ViralChildCommunicable Disease ControlCross-Sectional StudiesFranceHumansMiddle AgedPandemicsSARS-CoV-2Seroepidemiologic StudiesVulnerable PopulationsYoung AdultAntibodies, ViralCOVID-19epidemiologypublic health

Identifiers

PMID34815286
PMCPMC8611237
OpenAlexW3216933699

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.