ArticleReproductive biomedicine online2022
Does mRNA SARS-CoV-2 vaccine detrimentally affect male fertility, as reflected by semen analysis?
Article in Reproductive biomedicine online, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Effects of SARS-CoV-2 Vaccines on Sperm Quality: Systematic Review.JMIR public health and surveillance · 2023Pooled it
- Effect of COVID-19 vaccination on semen parameters: A systematic review and meta-analysis.Journal of medical virology · 2023Pooled it
- The effect of COVID-19 vaccines on sperm parameters: a systematic review and meta-analysis.Asian journal of andrology · 2023Pooled it
- Pooled it
- Endocrine system after 2 years of COVID-19 vaccines: A narrative review of the literature.Frontiers in endocrinology · 2022Pooled it
- Endocrine disorders following SARS-CoV-2 vaccination: a comprehensive systematic review.Clinical and experimental vaccine research · 2026Article
- Review
- SARS-CoV-2 vaccination and semen quality: a study based on sperm donor candidate data in southwest China.Translational andrology and urology · 2024Article
- Effects of COVID-19 vaccination on human fertility: a post-pandemic literature review.Annals of medicine · 2023Review
- SARS-CoV-2 and male infertility: from short- to long-term impacts.Journal of endocrinological investigation · 2023Review
- Seminal fluid changes in the COVID-19 era: During infection and Post-vaccination.Gynecology and obstetrics clinical medicine · 2023Review
- SARS-CoV-2, fertility and assisted reproduction.Human reproduction update · 2023Review
- Updates in the pathophysiology of COVID-19 infection in male reproductive and sexual health: a literature review.Frontiers in endocrinology · 2023Review
- Commentary on "The effect of COVID-19 vaccines on sperm parameters: a systematic review and meta-analysis".Asian journal of andrology · 2023Article
- Impact of inactivated COVID-19 vaccination on female ovarian reserve: a propensity score-matched retrospective cohort study.Frontiers in immunology · 2023Article
- Semen proteomics reveals alterations in fertility-related proteins post-recovery from COVID-19.Frontiers in physiology · 2023Article
- The effect of SARS-CoV-2 mRNA vaccination on AMH concentrations in infertile women.Reproductive biomedicine online · 2022Observational
- Impact of COVID-19 on male urogenital health: Success of vaccines.Drug discovery today · 2022Review
- mRNA and Viral Vector COVID-19 Vaccines Do Not Affect Male Fertility: A Prospective Study.The world journal of men's health · 2022Article
- Sperm quality is not affected by the BNT162b2 mRNA SARS-CoV-2 vaccine: results of a 6-14 months follow-up.Journal of assisted reproduction and genetics · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
research questionDoes Pfizer's coronavirus disease 2019 (COVID-19) vaccination detrimentally affect semen analysis parameters?
designA prospective cohort study was conducted at a single large tertiary centre in Israel between February and March of 2021. Semen samples from 75 fertile men were analysed 1-2 months following their second dose of Pfizer's COVID-19 vaccine. The semen parameters were compared with the World Health Organization (WHO) reference ranges. The primary outcome was the percentage of abnormal semen parameters in those who were vaccinated, i.e. the rates of oligozoospermia, reduced percentage of motile spermatozoa and abnormal sperm morphology.
resultsThe interval from the time of the second vaccination to the date of participation was on average 37 days, with most subjects describing either mild or no side effects after the first or second dose. The mean sperm concentration was 63.2 ± 33.6 × 10
conclusionsThe semen parameters following COVID-19 vaccination were predominantly within the normal reference ranges as set by the WHO and do not reflect any causative detrimental effect from COVID-19 vaccination. The results strengthen the notion that the Pfizer's severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine is safe and should be recommended to men wishing to conceive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.