ArticleMicrobiome2021
Microbiota in mesenteric adipose tissue from Crohn's disease promote colitis in mice.
Article in Microbiome, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06241170 (Mesentery Guided Bowel Resection Margin Versus Traditional Margin in Reducing Early Endoscopic Recurrence Rate After Ileocolic Resection in Patients With Crohn 's Disease), which is not on this map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mesentery Guided Bowel Resection Margin Versus Traditional Margin in Reducing Early Endoscopic Recurrence Rate After Ileocolic Resection in Patients With Crohn 's Disease:a Prospective, Multicenter, Randomized Controlled Clinical Trial
Who cites it
34 citing papers in PubMed, 50 citations in OpenAlex.
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- Genomic Insights Into Biocontrol and Plant Growth-Promoting Mechanisms of Paenibacillus maysiensis LHJ6 Against Root Rot in Panax notoginseng.Plant, cell & environment · 2026Article
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- Effects of Three DriedAquaculture nutrition · 2026Article
- Quantification of visceral adipose tissue volume predicts both short-term and long-term transmural healing in patients with Crohn's disease receiving Ustekinumab.Therapeutic advances in gastroenterology · 2026Article
- The role of lipid metabolism and creeping fat in disease assessment and prediction for Crohn's disease.Frontiers in immunology · 2026Review
- Gut Microbiota as a Mediator Between Intestinal Fibrosis and Creeping Fat in Crohn's Disease.United European gastroenterology journal · 2025Review
- Unveiling the diagnostic and pro-inflammatory role of crohn's disease: insights from 16 S-guided discovery and species-specific validation.BMC gastroenterology · 2025Article
- Gut microbiota in Crohn's disease pathogenesis.World journal of gastroenterology · 2025Review
- Creeping fat and gut microbiota in Crohn's disease.World journal of gastroenterology · 2025Review
- Parabacteroides absconsus sp. nov., isolated from feces of a child with atopic dermatitis.Archives of microbiology · 2025Article
- A Knowledge-Guided Large Language Model Framework for Microbiome-Based Disease Diagnosis.Proceedings. IEEE International Conference on Bioinformatics and Biomedicine · 2025Article
- Gut bacterial type III secretion systems aggravate colitis in mice and serve as biomarkers of Crohn's disease.EBioMedicine · 2024Article
- Diminished Immune Response and Elevated Abundance in Gut Microbe Dubosiella in Mouse Models of Chronic Colitis with GBP5 Deficiency.Biomolecules · 2024Article
- Tissue-resident bacteria in metabolic diseases: emerging evidence and challenges.Nature metabolism · 2024Review
- Abnormal adipose tissue-derived microbes drive metabolic disorder and exacerbate postnatal growth retardation in piglet.Life metabolism · 2024Article
- MSCs mediate long-term efficacy in a Crohn's disease model by sustained anti-inflammatory macrophage programming via efferocytosis.NPJ Regenerative medicine · 2024Article
- Translocation of gut microbes to epididymal white adipose tissue drives lipid metabolism disorder under heat stress.Science China. Life sciences · 2023Article
- Effect of Extracelluar Vesicles Derived fromNutrients · 2023Article
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMesenteric adipose tissue (mAT) hyperplasia, known as creeping fat is a pathologic characteristic of Crohn's disease (CD). The reserve of creeping fat in surgery is associated with poor prognosis of CD patients, but the mechanism remains unknown.
methodsMesenteric microbiome, metabolome, and host transcriptome were characterized using a cohort of 48 patients with CD and 16 non-CD controls. Multidimensional data including 16S ribosomal RNA gene sequencing (16S rRNA), host RNA sequencing, and metabolome were integrated to reveal network interaction. Mesenteric resident bacteria were isolated from mAT and functionally investigated both in the dextran sulfate sodium (DSS) model and in the Il10 gene-deficient (Il10
resultsMesenteric microbiota contributed to aberrant metabolites production and transcripts in mATs from patients with CD. The presence of mAT resident microbiota was associated with the development of CD. Achromobacter pulmonis (A. pulmonis) isolated from CD mAT could translocate to mAT and exacerbate both DSS-induced and Il10 gene-deficient (Il10
conclusionsThis study suggests that the mesenteric microbiota from patients with CD sculpt a detrimental microenvironment and promote intestinal inflammation. Video abstract.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.