Evidence map›Paper›PMID 34814943›Full record

ArticleChild and adolescent psychiatry and mental health2021

Harsh parenting and non-suicidal self-injury in adolescence: the mediating effect of depressive symptoms and the moderating effect of the COMT Val158Met polymorphism.

Jinmeng Liu, Xia Liu, Hui Wang, Yemiao Gao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Child and adolescent psychiatry and mental health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jinmeng LiuInstitute of Developmental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, 100875, China.
Xia LiuInstitute of Developmental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, 100875, China. liuxia@bnu.edu.cn.ORCID http://orcid.org/0000-0003-1136-4742
Hui WangInstitute of Developmental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, 100875, China.
Yemiao GaoInstitute of Developmental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, 100875, China.
Beijing Normal University · CN

Funding

National Natural Science Foundation of China 31900772
6 · The paper itself

Abstract

backgroundPrevious studies have suggested that negative parenting environments, especially harsh parenting, are a specific risk factor for non-suicidal self-injury (NSSI). However, the potential mechanism between harsh parenting and NSSI has not been explored. Based on the experiential avoidance model and empirical research, we aimed to examine whether depressive symptoms are a mediator between harsh parenting and NSSI. Moreover, the catechol-O-methyltransferase (COMT) Val158Met polymorphism related to depressive symptoms may also exert a moderating effect on NSSI; thus, the interaction between harsh parenting and COMT was also considered in our study.

methodsA total of 373 junior high school students were recruited for the study by using a longitudinal design. The adolescents answered self-report questionnaires and provided saliva samples for DNA genotyping.

resultsThe results revealed that harsh parenting was positively associated with NSSI after 24 months, and this association was mediated by depressive symptoms. Moreover, the moderating role of COMT in the direct and indirect effects of harsh parenting on NSSI was observed only among adolescents with two Val alleles and the relationship was not significant for Met carriers.

conclusionsGenetic variations of COMT Val158Met may be a critical candidate in understanding the development of depression and NSSI. We conclude that Val homozygotes of the COMT Val158Met polymorphism play a role in susceptibility to both depressive symptoms and NSSI.

Indexed as

COMT Val158Met polymorphismDepressive symptomsHarsh parentingNon-suicidal self-injury

Identifiers

PMID34814943
PMCPMC8611980
OpenAlexW3216892598

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.