ArticleBMC medicine2021
Adherence to the Mediterranean diet assessed by a novel dietary biomarker score and mortality in older adults: the InCHIANTI cohort study.
Article in BMC medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01331512 (The InChianti Follow-Up Study), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The InChianti Follow-Up Study
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mediterranean diet and rheumatoid arthritis: A nine-year cohort study and systematic review with meta-analysis.European journal of clinical nutrition · 2025Pooled it
- Gender and sex differences in adherence to a Mediterranean diet and associated factors during the COVID-19 pandemic: a systematic review.Frontiers in nutrition · 2024Pooled it
- Trial
- Effect of a multicomponent intervention on adherence to the Mediterranean diet in older adults: a randomized controlled trial.Frontiers in nutrition · 2026Article
- Mediterranean diet impact on plasma proteins: biomarker networks linking nutrition to the modulation of inflammation and oxidative stress.Frontiers in nutrition · 2026Review
- The polyunsaturated-to-monounsaturated fatty acid ratio and cardiovascular risk prediction: a prospective cohort study of 183,237 adults.Lipids in health and disease · 2025Article
- The role of Mediterranean diet in cancer incidence and mortality in the older adults.npj aging · 2024Article
- Towards nutrition with precision: unlocking biomarkers as dietary assessment tools.Nature metabolism · 2024Review
- Precision Nutrition and Cardiovascular Disease Risk Reduction: the Promise of High-Density Lipoproteins.Current atherosclerosis reports · 2023Review
- Which Factors Influence Healthy Aging? A Lesson from the Longevity Village of Bama in China.Aging and disease · 2023Review
- Mediterranean Diet Adherence Is Associated with Favorable Health-Related Quality of Life, Physical Activity, and Sleep Quality in a Community-Dwelling Greek Older Population.Antioxidants (Basel, Switzerland) · 2023Article
- Article
- Comparison and convergent validity of five Mediterranean dietary indexes applied to Brazilian adults and older adults: data from a population-based study (2015 ISA-Nutrition): a critical analysis.Journal of nutritional science · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundDietary biomarkers may complement dietary intake assessment made by dietary questionnaires. We developed an a-posteriori dietary biomarkers score based on Mediterranean diet food groups and evaluated its association with mortality.
methods642 participants (56% female), aged ≥65 years, with complete data on dietary biomarkers were followed during 20 years in the InCHIANTI cohort study (Tuscany, Italy). The main outcomes were all-cause, cardiovascular, and cancer mortality. Dietary biomarkers were selected from literature and from correlation analyses with dietary intakes of Mediterranean diet food groups in the study. The baseline levels of the following dietary biomarkers were chosen: urinary total polyphenols and resveratrol metabolites, and plasma carotenoids, selenium, vitamin B12, linolenic, eicosapentaenoic and docosahexaenoic acids, and the mono-unsaturated/saturated fatty acid ratio. Associations of the Mediterranean diet score using dietary biomarkers and a validated food frequency questionnaire (FFQ) (as tertiles) with mortality were assessed through Cox regression.
resultsDuring the 20-year follow-up [median (Q1-Q3), 14 (8-18) years], and 435 deaths occurred (139 from cardiovascular diseases and 89 from cancer-related causes). In the fully adjusted models, the dietary biomarker-Mediterranean diet score was inversely associated with all-cause (HR
conclusionsA greater adherence at baseline to a Mediterranean diet assessed by a dietary biomarker score was associated with a lower risk of mortality in older adults during a 20-year follow-up. The measurement of dietary biomarkers may contribute to guide individualized dietary counseling to older people.
trial registrationNCT01331512.
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