Evidence map›Paper›PMID 34814777›Full record

Observational studyThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2022

Prospective evaluation of placental abruption in nulliparous women.

Amir Lueth, Nathan Blue, Robert M Silver, Amanda Allshouse, Matthew Hoffman, William A Grobman, Hyagriv N Simhan, Uma Reddy, David M Haas

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Bloody Amniotic Fluid and Neonatal Outcomes.Children (Basel, Switzerland) · 2023
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Amir LuethDepartment of Obstetrics and Gynecology, University of Utah Health Care, Salt Lake City, UT, USA.ORCID 0000-0002-2373-9372
Nathan BlueDepartment of Obstetrics and Gynecology, University of Utah Health Care, Salt Lake City, UT, USA.
Robert M SilverDepartment of Obstetrics and Gynecology, University of Utah Health Care, Salt Lake City, UT, USA.
Amanda AllshouseDepartment of Obstetrics and Gynecology, University of Utah Health Care, Salt Lake City, UT, USA.
Matthew HoffmanDepartment of Obstetrics and Gynecology, Christiana Care Health System, Newark, DE, USA.ORCID 0000-0002-2927-8693
William A GrobmanDepartment of Obstetrics and Gynecology, Northwestern University, Chicago, IL, USA.
Hyagriv N SimhanDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Women's Hospital of UPMC, Pittsburgh, PA, USA.
Uma ReddyDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.
David M HaasDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, USA.
University of Utah Health Care · USChristiana Care Health System · USIndiana University School of MedicineMagee-Womens Hospital · USNorthwestern University · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Preterm Birth in Nulliparous Women: An Understudied Population at Great RiskU10HD063053 · NICHD · UNIVERSITY OF UTAH · PI SILVER, ROBERT M. · 2010 to 2014
$1.7M
Preterm Birth in Nulliparous Women: An Understudied Population at Great Risk U10HD063020 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GROBMAN, WILLIAM ADAM · 2010 to 2014
$1.6M
Dissecting the Genetic Etiology of Preterm Birth in Nulliparous WomenU10HD063037 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI HAAS, DAVID M. · 2010 to 2014
$1.2M
NCATS NIH HHS UL1 TR001863NICHD NIH HHS U10 HD063020NICHD NIH HHS U10 HD063037NICHD NIH HHS U10 HD063053
6 · The paper itself

Abstract

introductionBecause most data on placental abruption are derived from retrospective studies, multiple sources of bias may have affected the results. Thus, we aimed to characterize risk factors and outcomes for placental abruption in a large prospective cohort of nulliparous women.

methodsThis was a secondary analysis of women enrolled in the Nulliparous Pregnancy Outcomes Study Monitoring-to-be (nuMom2b) study, a prospective observational cohort. Participants were recruited in their first trimester of pregnancy from 8 sites and had 4 study visits, including at delivery. Placental abruption was defined by confirmed clinical criteria. The primary analysis was restricted to abruption identified antepartum and intrapartum. As a secondary analysis, we examined antepartum and intrapartum abruptions separately. We compared risk factors (maternal demographic and clinical characteristics) and outcomes in women with and without placental abruption using univariable and multivariable analyses as appropriate.

results9450 women were included in the primary analysis. Abruption was identified in 0.66% (

conclusionAbruption was identified in <1% of nulliparous women. However, few maternal risk factors were identified. Neonatal morbidities were associated with an abruption and were primarily driven by gestational age due to preterm birth.

Indexed as

Abruptio PlacentaePremature BirthFemaleHumansInfant, NewbornPlacentaPregnancyPregnancy OutcomeRetrospective StudiesRisk Factorsadverse pregnancy outcomesneonatal outcomesperinatal morbidityPlacental abruption

Identifiers

PMID34814777
PMCPMC9678005
OpenAlexW3214862544

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.