Evidence map›Paper›PMID 34814733›Full record

ReviewJournal of the Royal Society, Interface2021

Transcatheter aortic valve thrombosis: a review of potential mechanisms.

Vrishank Raghav, Prem Midha, Rahul Sharma, Vasilis Babaliaros, Ajit Yoganathan

Open access · greenAbstract readReview
In one paragraph

Review in Journal of the Royal Society, Interface, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 1 country.

Vrishank RaghavDepartment of Aerospace Engineering, Auburn University, Auburn, AL, USA.ORCID 0000-0001-8667-4409
Prem MidhaAbbott Laboratories, Abbott Park, IL, USA.
Rahul SharmaInterventional Cardiology, Cardiovascular Medicine Faculty, Stanford University, Stanford, CA, USA.
Vasilis BabaliarosDivision of Cardiology, Emory Structural Heart and Valve Center, Emory University, Atlanta, GA, USA.
Ajit YoganathanWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology & Emory University, Atlanta, GA, USA.ORCID 0000-0001-5818-1316
Abbott Fund · USAuburn University · USEmory University · USGeorgia Institute of Technology · USStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcatheter aortic valve (TAV) thrombosis has been recognized as a significant problem that sometimes occurs as early as within 30 days after valve implantation, leading to increased concerns of stroke and long-term valve durability. In this article, a critical summary of the relevant literature on identifying potential mechanisms of TAV thrombosis from the perspective of the well-known Virchow's triad, which comprises blood flow, foreign materials and blood biochemistry, is presented. Blood flow mechanisms have been the primary focus thus far, with a general consensus on the flow mechanisms with respect to haemodynamic conditions, the influence of TAV placement and expansion and the influence of coronary flow. Less attention has been paid to the influence of blood biochemistry and foreign materials (and related endothelial damage), with little consensus among studies with regards to platelet and/or microparticle levels post-TAV implantation. Finally, we discuss the future outlook for research with unanswered scientific questions.

Indexed as

Aortic Valve StenosisHeart Valve ProsthesisThrombosisTranscatheter Aortic Valve ReplacementAortic ValveHumansmechanismsthrombosistranscatheter aortic valve

Identifiers

PMID34814733
PMCPMC8611327
OpenAlexW3216615034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.