ArticleCirculation2022
Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease.
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Article in Circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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63 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Large-scale circulating proteome association study (CPAS) meta-analysis identifies circulating proteins and pathways predicting incident hip fractures.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Pooled it
- Polymorphic Variant Associated with Sex Hormone-Binding Globulin Level Is a Risk Factor for Preeclampsia.International journal of molecular sciences · 2026Article
- Genetic drivers of protein changes over time: Findings, considerations, and approaches in TOPMed cohorts and UK Biobank.bioRxiv : the preprint server for biology · 2026Article
- Cross-population proteome-wide mendelian randomization study identifies likely causal proteins for cardiovascular diseases.Molecular genetics and genomics : MGG · 2026Article
- Nanoparticle-enriched mass spectrometry proteomics in British South Asians identifies links between genetic variants, plasma protein levels and disease risk.Nature genetics · 2026Article
- Modular PheWAS reveals the therapeutic heterogeneity landscape of Danghong injection on stable angina pectoris.Molecular biomedicine · 2026Article
- Apolipoprotein variations across APOE genotypes in young and elderly patients with coronary heart disease.Bioscience reports · 2026Article
- Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome.Cell · 2026Article
- Unraveling Atherosclerosis through Multi-omics: Systematic Insights into the Unique Applications and Clinical Perspectives.Current atherosclerosis reports · 2026Review
- Sex-specific omics scores of sex hormones and associations with metabolic and sleep disorders.medRxiv : the preprint server for health sciences · 2026Article
- Article
- Plasma Proteins Associated With Psychosocial Factors and Heart Disease: The Jackson Heart Study.Arteriosclerosis, thrombosis, and vascular biology · 2026Article
- Multi-omic responses to acute exercise in abdominal subcutaneous adipose tissue of sedentary adults: findings from MoTrPAC.bioRxiv : the preprint server for biology · 2026Article
- Blood Biochemical Responses to Acute Exercise: Findings from the Molecular Transducers of Physical Activity Consortium (MoTrPAC).bioRxiv : the preprint server for biology · 2026Article
- Multi-Omic, Multi-Tissue Responses to Acute Exercise in Sedentary Adults: Findings from the Molecular Transducers of Physical Activity Consortium.bioRxiv : the preprint server for biology · 2026Article
- Admixture-mapping analysis reveals genetic determinants of the human plasma proteome.HGG advances · 2026Observational
- Plasma proteomics and incident coronary heart disease.Communications medicine · 2026Article
- Large-Scale Protein Assay Identifies Novel Protein Biomarkers Associated With Arterial Stiffness and Vascular Calcification Measures.International journal of hypertension · 2026Article
- Prediction of Major Adverse Cardiovascular Events in Peripheral Artery Disease: Integrating Metabolomics and Proteomics for Risk Stratification.Research (Washington, D.C.) · 2026Article
- Olink Proteomics in Heart Failure: A Comprehensive Review of Applications From Biomarker Discovery to Pathophysiological Insights and Clinical Implementation.Reviews in cardiovascular medicine · 2026Review
3 more citing papers are in PubMed but not listed here.
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Authors and funding
37 authors at 11 institutions in 1 country.
Daniel H Katz *Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., J.M.R., Z.-Z.C., D.E.C., S.D., L.F., S.S., A.A.S., D.S., J.G.W., R.E.G.).ORCID 0000-0001-7237-8502
Usman A Tahir *Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., J.M.R., Z.-Z.C., D.E.C., S.D., L.F., S.S., A.A.S., D.S., J.G.W., R.E.G.).
Alexander G Bick *Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge (A.G.B., A.P., Z.Y., P.N., R.E.G.).ORCID 0000-0001-5824-9595
Akhil PampanaBroad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge (A.G.B., A.P., Z.Y., P.N., R.E.G.).ORCID 0000-0002-4167-0540
Debby NgoDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., J.M.R., Z.-Z.C., D.E.C., S.D., L.F., S.S., A.A.S., D.S., J.G.W., R.E.G.).ORCID 0000-0003-2681-3475
Mark D BensonDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., J.M.R., Z.-Z.C., D.E.C., S.D., L.F., S.S., A.A.S., D.S., J.G.W., R.E.G.).
Zhi YuUniversity of Mississippi Medical Center, Jackson (Y.G., M.E.H., A.C.).ORCID 0000-0003-4810-3474
Jeremy M RobbinsDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., J.M.R., Z.-Z.C., D.E.C., S.D., L.F., S.S., A.A.S., D.S., J.G.W., R.E.G.).ORCID 0000-0002-9672-4841
Zsu-Zsu ChenDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., J.M.R., Z.-Z.C., D.E.C., S.D., L.F., S.S., A.A.S., D.S., J.G.W., R.E.G.).ORCID 0000-0001-9441-675X
Daniel E CruzDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., J.M.R., Z.-Z.C., D.E.C., S.D., L.F., S.S., A.A.S., D.S., J.G.W., R.E.G.).
Shuliang DengDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., J.M.R., Z.-Z.C., D.E.C., S.D., L.F., S.S., A.A.S., D.S., J.G.W., R.E.G.).
Laurie FarrellDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., J.M.R., Z.-Z.C., D.E.C., S.D., L.F., S.S., A.A.S., D.S., J.G.W., R.E.G.).
Sumita SinhaDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., J.M.R., Z.-Z.C., D.E.C., S.D., L.F., S.S., A.A.S., D.S., J.G.W., R.E.G.).
Alec A SchmaierDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., J.M.R., Z.-Z.C., D.E.C., S.D., L.F., S.S., A.A.S., D.S., J.G.W., R.E.G.).
Dongxiao ShenDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., J.M.R., Z.-Z.C., D.E.C., S.D., L.F., S.S., A.A.S., D.S., J.G.W., R.E.G.).ORCID 0000-0003-4164-0402
Yan GaoUniversity of Mississippi Medical Center, Jackson (Y.G., M.E.H., A.C.).
Michael E HallUniversity of Mississippi Medical Center, Jackson (Y.G., M.E.H., A.C.).ORCID 0000-0002-5733-1025
Adolfo CorreaUniversity of Mississippi Medical Center, Jackson (Y.G., M.E.H., A.C.).ORCID 0000-0002-9501-600X
Russell P TracyDepartment of Pathology Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington (R.P.T., P.D.).
Peter DurdaDepartment of Pathology Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington (R.P.T., P.D.).
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-University of California, Los Angeles, Medical Center, Torrance (K.D.T., X.G., J.Y., Y.-D.I.C., J.I.R.).ORCID 0000-0002-2756-4370
Yongmei LiuDepartment of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC (Y.L.).
W Craig JohnsonDepartment of Biostatistics (W.C.J.), University of Washington, Seattle.ORCID 0000-0002-3161-3753
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-University of California, Los Angeles, Medical Center, Torrance (K.D.T., X.G., J.Y., Y.-D.I.C., J.I.R.).ORCID 0000-0002-5264-5068
Jie YaoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-University of California, Los Angeles, Medical Center, Torrance (K.D.T., X.G., J.Y., Y.-D.I.C., J.I.R.).ORCID 0000-0002-8822-0651
Yii-Der Ida ChenInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-University of California, Los Angeles, Medical Center, Torrance (K.D.T., X.G., J.Y., Y.-D.I.C., J.I.R.).
Ani W ManichaikulCenter for Public Health Genomics (A.W.M., S.S.R.), University of Virginia, Charlottesville.
Deepti JainUniversity of Washington, Seattle (D.J.).
Claude BouchardHuman Genomic Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA (C.B.).ORCID 0000-0002-0048-491X
Mark A SarzynskiDepartment of Exercise Science, University of South Carolina, Columbia (M.A.S.).ORCID 0000-0001-6705-0668
Stephen S RichCenter for Public Health Genomics (A.W.M., S.S.R.), University of Virginia, Charlottesville.ORCID 0000-0003-3872-7793
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-University of California, Los Angeles, Medical Center, Torrance (K.D.T., X.G., J.Y., Y.-D.I.C., J.I.R.).ORCID 0000-0001-7191-1723
Thomas J WangDepartment of Medicine, University of Texas Southwestern Medical Center, Dallas (T.J.W.).ORCID 0000-0003-4063-6508
James G WilsonDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., J.M.R., Z.-Z.C., D.E.C., S.D., L.F., S.S., A.A.S., D.S., J.G.W., R.E.G.).
Pradeep NatarajanBroad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge (A.G.B., A.P., Z.Y., P.N., R.E.G.).ORCID 0000-0001-8402-7435
Robert E GersztenDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (D.H.K., U.A.T., D.N., M.D.B., J.M.R., Z.-Z.C., D.E.C., S.D., L.F., S.S., A.A.S., D.S., J.G.W., R.E.G.).ORCID 0000-0002-6767-7687
National Heart, Lung, and Blood Institute TOPMed (Trans-Omics for Precision Medicine) Consortium†
Beth Israel Deaconess Medical Center · USLos Angeles Biomedical Research Institute · USUniversity of Mississippi Medical Center · USBroad Institute · USUniversity of Virginia · USDuke Medical Center · USUniversity of Vermont · USUniversity of Washington · USPennington Biomedical Research Center · USThe University of Texas Southwestern Medical Center · USUniversity of South Carolina · US
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MSouth Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Mohamad Habes · 2021 to 2026
$24.0MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MUtilizing the Phenomics of IBD to Enhance Gene DiscoveryU01DK062413 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI Dermot Patrick McGovern · 2002 to 2026
$12.2MStudies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5MMetabolomic predictors of insulin resistance and diabetesR01DK081572 · NIDDK · VANDERBILT UNIVERSITY · PI CLISH, CLARY B, GERSZTEN, ROBERT E · 2008 to 2025
$9.3MRare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
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Abstract
backgroundPlasma proteins are critical mediators of cardiovascular processes and are the targets of many drugs. Previous efforts to characterize the genetic architecture of the plasma proteome have been limited by a focus on individuals of European descent and leveraged genotyping arrays and imputation. Here we describe whole genome sequence analysis of the plasma proteome in individuals with greater African ancestry, increasing our power to identify novel genetic determinants.
methodsProteomic profiling of 1301 proteins was performed in 1852 Black adults from the Jackson Heart Study using aptamer-based proteomics (SomaScan). Whole genome sequencing association analysis was ascertained for all variants with minor allele count ≥5. Results were validated using an alternative, antibody-based, proteomic platform (Olink) as well as replicated in the Multi-Ethnic Study of Atherosclerosis and the HERITAGE Family Study (Health, Risk Factors, Exercise Training and Genetics).
resultsWe identify 569 genetic associations between 479 proteins and 438 unique genetic regions at a Bonferroni-adjusted significance level of 3.8×10
conclusionsTaken together, these results provide evidence for the functional importance of variants in non-European populations, and suggest new biological mechanisms for ancestry-specific determinants of lipids, coagulation, and myocardial function.
Indexed as
AdultBlack PeopleCardiovascular DiseasesFemaleGenome-Wide Association StudyHumansMaleProteomeProteomecardiovascular diseasegeneticsproteomicsrace and ethnicity
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