ArticleJournal of movement disorders2022
The Supplementary Motor Complex in Parkinson's Disease.
Article in Journal of movement disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07190235 (The Effect of Repetitive Transcranial Magnetic Stimulation Over the Supplementary Motor Area on Gait Performance in Parkinson's Disease), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Repetitive Transcranial Magnetic Stimulation Over the Supplementary Motor Area on Gait Performance in Parkinson's Disease: A Randomized Controlled Trial
Who cites it
22 citing papers in PubMed.
- Bilateral intermittent theta-burst stimulation as a priming strategy to enhance action observation and imitation training in early parkinson's disease: a proof-of-concept study.Journal of neuroengineering and rehabilitation · 2025Trial
- Neural correlates of fine motor grasping skills: Longitudinal insights into motor cortex activation using fNIRS.Brain and behavior · 2024Trial
- Dissociable Handwriting Domains in Parkinson's Disease?Movement disorders clinical practice · 2026Article
- Higher cortical beta oscillatory power before balance perturbations is associated with worse balance in older adults with Parkinson's Disease, but not in age-matched older adults.bioRxiv : the preprint server for biology · 2026Article
- Exploring fNIRS-guided neurofeedback for supplementary motor area training in Parkinson's disease and healthy older adults.NPJ Parkinson's disease · 2026Article
- Disrupted neural response timing and duration during hand movement preparation in schizophrenia spectrum disorder: An fMRI study.Scientific reports · 2026Article
- Quadrato Motor Training in Parkinson's Disease: Resting-State fMRI Changes and Exploratory Whole-Brain Radiomics.Bioengineering (Basel, Switzerland) · 2026Article
- Effect of repetitive transcranial magnetic stimulation modulating supplementary motor area in stroke rehabilitation: Systematic review of randomized controlled trials.AIMS neuroscience · 2026Review
- Preoperative network activity predicts the response to subthalamic DBS for Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- A Pilot Study on the Influence of Self-Paced Auditory Cues and Preferred Music on Gait in Persons with Parkinson's Disease.Brain sciences · 2025Article
- Modulatory effect of levodopa on the basal ganglia-cerebellum connectivity in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Parkinsonism Disrupts Neuronal Modulation in the Presupplementary Motor Area during Movement Preparation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Role of right dorsolateral prefrontal cortex-left primary motor cortex interaction in motor inhibition in Parkinson's disease.Frontiers in aging neuroscience · 2025Article
- Functional anatomy of the subthalamic nucleus and the pathophysiology of cardinal features of Parkinson's disease unraveled by focused ultrasound ablation.Science advances · 2024Article
- Static and Dynamic Functional Network Connectivity in Parkinson's Disease Patients With Postural Instability and Gait Disorder.CNS neuroscience & therapeutics · 2024Article
- Combining Transcranial Direct Current Stimulation with Exercise to Improve Mobility, Stability, and Tremor Management in 25 Individuals with Parkinson's Disease.Neurology international · 2024Article
- Cortical networks of parkinsonian gait: a metabolic and functional connectivity study.Annals of clinical and translational neurology · 2024Article
- Affection of Motor Network Regions by Tau Pathology Across the Alzheimer's Disease Spectrum.eNeuro · 2024Article
- Parkinson's Disease Risk Variant rs9638616 is Non-Specifically Associated with Altered Brain Structure and Function.Journal of Parkinson's disease · 2024Article
- Cortical and subcortical morphological alterations in motor subtypes of Parkinson's disease.NPJ Parkinson's disease · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder characterized by both motor and nonmotor symptoms. Although the basal ganglia is traditionally the primary brain region implicated in this disease process, this limited view ignores the roles of the cortex and cerebellum that are networked with the basal ganglia to support motor and cognitive functions. In particular, recent research has highlighted dysfunction in the supplementary motor complex (SMC) in patients with PD. Using the PubMed and Google Scholar search engines, we identified research articles using keywords pertaining to the involvement of the SMC in action sequencing impairments, temporal processing disturbances, and gait impairment in patients with PD. A review of abstracts and full-text articles was used to identify relevant articles. In this review of 63 articles, we focus on the role of the SMC in PD, highlighting anatomical and functional data to create new perspectives in understanding clinical symptoms and, potentially, new therapeutic targets. The SMC has a nuanced role in the pathophysiology of PD, with both hypo- and hyperactivation associated with various symptoms. Further studies using more standardized patient populations and functional tasks are needed to more clearly elucidate the role of this region in the pathophysiology and treatment of PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.