Evidence map›Paper›PMID 34814105›Full record

ArticleThe American journal of tropical medicine and hygiene2021

Serological Evidence of Zika Virus Infection in Febrile Patients and Healthy Blood Donors in Sabah, Malaysian Borneo, 2017-2018.

Mya Myat Ngwe Tun, Daisuke Mori, Shahnaz Binti Sabri, Omar Kugan, Saliz Binti Shaharom, Jecelyn John, Aung Min Soe, Khine Mya Nwe, Jiloris Frederick Dony, Shingo Inoue and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Mya Myat Ngwe TunDepartment of Virology, Institute of Tropical Medicine and Leading Program, Nagasaki University, Nagasaki, Japan.
Daisuke MoriDepartment of Pathology and Microbiology, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia.
Shahnaz Binti SabriDepartment of Transfusion Medicine, Queen Elizabeth Hospital II, Ministry of Health Malaysia, Kota Kinabalu, Sabah, Malaysia.
Omar KuganPutatan District Health Office, Ministry of Health Malaysia, Putatan, Sabah, Malaysia.
Saliz Binti ShaharomDepartment of Transfusion Medicine, Queen Elizabeth Hospital II, Ministry of Health Malaysia, Kota Kinabalu, Sabah, Malaysia.
Jecelyn JohnBorneo Medical and Health Research Center, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia.
Aung Min SoeDepartment of Virology, Institute of Tropical Medicine and Leading Program, Nagasaki University, Nagasaki, Japan.
Khine Mya NweDepartment of Virology, Institute of Tropical Medicine and Leading Program, Nagasaki University, Nagasaki, Japan.
Jiloris Frederick DonyKota Kinabalu Public Health Laboratory, Sabah State Health Department, Ministry of Health Malaysia, Kota Kinabalu, Sabah, Malaysia.
Shingo InoueDepartment of Virology, Institute of Tropical Medicine and Leading Program, Nagasaki University, Nagasaki, Japan.
Kouichi MoritaDepartment of Virology, Institute of Tropical Medicine and Leading Program, Nagasaki University, Nagasaki, Japan.
Kamruddin AhmedDepartment of Pathology and Microbiology, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia.
Nagasaki University · JPUniversiti of Malaysia Sabah · MYMinistry of Health · MYQueen Elizabeth Hospital · MY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several Zika virus (ZIKV) seroprevalence studies have been conducted in Africa, Asia, Oceania, the Americas, and the Caribbean. However, studies on ZIKV seroprevalence are limited in Malaysia though several studies have shown that the disease is endemic in the Malaysian state of Sabah. To evaluate the seroprevalence of ZIKV infection, 818 serum samples were collected from febrile patients and healthy blood donors from the Kudat and Kota Kinabalu districts in Sabah from 2017 to 2018. They were screened for ZIKV infection by IgM and IgG ELISA, and positive ZIKV IgM samples were subjected to a 90% neutralization test for confirmation. Twenty-four (6% [95% CI 4 to 8]) confirmed and two (0.5% [95% CI 0.13 to 1.8]) probable ZIKV infections were detected among 400 febrile illness patients. Of 418 healthy blood donor samples, six (1.4% [95% CI 0.65 to 3]) were determined as confirmed ZIKV infections and six (1.4% [95% CI 0.65 to 3]) indicated probable ZIKV infection. This is the first study on the seroprevalence of ZIKV infections among patients and healthy blood donors in Sabah. Compared with previous studies in Malaysia, this study shows that the incidence of ZIKV infection has increased. It also suggests that a sero-surveillance system is essential to determine the circulation of ZIKV in Sabah, Malaysia.

Indexed as

Blood DonorsAdolescentAdultAntibodies, ViralBorneoChildChild, PreschoolFemaleFeverHumansImmunoglobulin GInfantMalaysiaMaleMiddle AgedNeutralization TestsAntibodies, ViralImmunoglobulin G

Identifiers

PMID34814105
PMCPMC8832921
OpenAlexW3214995651

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.