Evidence map›Paper›PMID 34813771›Full record

ArticleAmerican heart journal2022

Is the affordable care act medicaid expansion associated with receipt of heart failure guideline-directed medical therapy by race and ethnicity?

Khadijah K Breathett, Haolin Xu, Nancy K Sweitzer, Elizabeth Calhoun, Roland A Matsouaka, Clyde W Yancy, Gregg C Fonarow, Adam D DeVore, Deepak L Bhatt, Pamela N Peterson

Open access · greenAbstract read
In one paragraph

Article in American heart journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Khadijah K BreathettDivision of Cardiovascular Medicine, Sarver Heart Center, University of Arizona, Tucson, AZ. Electronic address: dijikb@gmail.com.
Haolin XuDepartment of Biostatistics and Bioinformatics, Duke University, Durham, NC.
Nancy K SweitzerDivision of Cardiovascular Medicine, Sarver Heart Center, University of Arizona, Tucson, AZ.
Elizabeth CalhounCenter for Population Science and Discovery, University of Arizona, Tucson, AZ.
Roland A MatsouakaDepartment of Biostatistics and Bioinformatics, Duke University, Durham, NC.
Clyde W YancyDivision of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL.
Gregg C FonarowDivision of Cardiology, University of California Los Angeles, CA.
Adam D DeVoreDivision of Cardiology, Duke University, Durham, NC.
Deepak L BhattDivision of Cardiovascular Medicine, Brigham and Women's Hospital Heart & Vascular Center, Harvard Medical School, Boston, MA.
Pamela N PetersonDivision of Cardiology, University of Colorado, Anschutz Medical Campus, Aurora, CO; Division of Cardiology, Denver Health Medical Center, Denver, CO.
Duke University · USUniversity of Arizona · USBrigham and Women's Hospital · USDenver Health Medical Center · USNorthwestern University · USUniversity of California, Los Angeles · US

Funding

UCSF Research in Implementation Sciences for Equity (RISE)R25HL126146 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRYSTAL WILEY CENE, Alicia Fernandez · 2014 to 2026
$4.6M
Seeking Objectivity in Allocation of Advanced Heart Failure (SOCIAL HF) Therapies TrialR56HL159216 · NHLBI · UNIVERSITY OF ARIZONA · PI BREATHETT, KHADIJAH · 2021 to 2021
$906k
Addressing Individual Provider Bias and Group Decision-Making in Selection of Advanced Heart Failure Therapies in Racial/Ethnic MinoritiesK01HL142848 · NHLBI · UNIVERSITY OF ARIZONA · PI BREATHETT, KHADIJAH · 2018 to 2021
$858k
NHLBI NIH HHS K01 HL142848NHLBI NIH HHS L30 HL148881NHLBI NIH HHS R25 HL126146NHLBI NIH HHS R56 HL159216
6 · The paper itself

Abstract

backgroundUninsurance is a known contributor to racial/ethnic health inequities. Insurance is often needed for prescriptions and follow-up appointments. Therefore, we determined whether the Affordable Care Act(ACA) Medicaid Expansion was associated with increased receipt of guideline-directed medical treatment(GDMT) at discharge among patients hospitalized with heart failure(HF) by race/ethnicity.

methodsUsing Get With The Guidelines-HF registry, logistic regression was used to assess odds of receiving GDMT(HF medications; education; follow-up appointment) in early vs non-adopter states before(2012 - 2013) and after ACA Medicaid Expansion(2014 - 2019) within each race/ethnicity, accounting for patient-level covariates and within-hospital clustering. We tested for an interaction(p-int) between GDMT and pre/post Medicaid Expansion time periods.

resultsAmong 271,606 patients(57.5% early adopter, 42.5% non-adopter), 65.5% were White, 22.8% African American, 8.9% Hispanic, and 2.9% Asian race/ethnicity. Independent of ACA timing, Hispanic patients were more likely to receive all GDMT for residing in early adopter states compared to non-adopter states (P <.0001). In fully-adjusted analyses, ACA Medicaid Expansion was associated with higher odds of receipt of ACEI/ARB/ARNI in Hispanic patients [before ACA:OR 0.40(95%CI:0.13,1.23); after ACA:OR 2.46(1.10,5.51); P-int = .0002], but this occurred in the setting of an immediate decline in prescribing patterns, particularly among non-adopter states, followed by an increase that remained lowest in non-adopter states. The ACA was not associated with receipt of GDMT for other racial/ethnic groups.

conclusionsAmong GWTG-HF hospitals, Hispanic patients were more likely to receive all GDMT if they resided in early adopter states rather than non-adopter states, independent of ACA Medicaid Expansion timing. ACA implementation was only associated with higher odds of receipt of ACEI/ARB/ARNI in Hispanic patients. Additional steps are needed for improved GDMT delivery for all.

Indexed as

Heart FailurePatient Protection and Affordable Care ActAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsEthnicityHumansInsurance CoverageMedicaidUnited StatesAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor Antagonistsevidence-based medicinehealth policyheart failurehospitalization

Identifiers

PMID34813771
PMCPMC8727506
OpenAlexW3215136847

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.