Evidence map›Paper›PMID 34813674›Full record

SynthesisEnvironmental toxicology and chemistry2022

Development of Fluoride Protective Values for Aquatic Life Using Empirical Bioavailability Models.

Samuel P Parker, Austin E Wilkes, Gary R Long, Nigel W E Goulding, Rajat S Ghosh

Abstract readMeta-AnalysisReview
In one paragraph

Synthesis in Environmental toxicology and chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Samuel P ParkerEHS Support, Waterbury, Vermont, USA.
Austin E WilkesEHS Support, Hinesburg, Vermont, USA.
Gary R LongEHS Support, Collegeville, Pennsylvania, USA.
Nigel W E GouldingEHS Support, Columbus, Ohio, USA.
Rajat S GhoshAlcoa, Pittsburgh, Pennsylvania, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The derivation of protective values for aquatic life can be enhanced by the development and use of bioavailability models. Recent advances to metals bioavailability modeling are applicable to other analyte groups and should be widely considered. We conducted a meta-analysis of the available aquatic toxicity literature for fluoride to evaluate the utility of hardness, alkalinity, and chloride as toxicity-modifying factors (TMFs) in empirical bioavailability models of freshwater taxa. The resulting optimal multiple linear regression model predicting acute fluoride toxicity to the invertebrate Hyalella azteca included all three TMFs (observed vs. predicted 50% lethal concentrations, R

Indexed as

Oncorhynchus mykissWater Pollutants, ChemicalAnimalsBiological AvailabilityChloridesFluoridesChloridesFluoridesWater Pollutants, ChemicalAquaticBenchmarkBioavailabilityEffectFluorideGuideline

Identifiers

PMID34813674
PMCPMC9303462

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.