Evidence map›Paper›PMID 34813308›Full record

ArticleJournal of the American Chemical Society2021

Evidence for an Enzyme-Catalyzed Rauhut-Currier Reaction during the Biosynthesis of Spinosyn A.

Sei-Hyun Choi, Byungsun Jeon, Namho Kim, Hsin-Hui Wu, Tzu-Ping Ko, Mark W Ruszczycky, Eta A Isiorho, Yung-Nan Liu, Adrian T Keatinge-Clay, Ming-Daw Tsai and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Reinvestigation of theJournal of the American Chemical Society · 2025
    Article
  3. Natural product reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sei-Hyun ChoiDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
Byungsun JeonDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
Namho KimDivision of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, United States.
Hsin-Hui WuInstitute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan.
Tzu-Ping KoInstitute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan.ORCID 0000-0003-1794-2638
Mark W RuszczyckyDivision of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, United States.
Eta A IsiorhoDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
Yung-Nan LiuDivision of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, United States.
Adrian T Keatinge-ClayDepartment of Molecular Biosciences, University of Texas at Austin, Austin, Texas 78712, United States.
Ming-Daw TsaiInstitute of Biological Chemistry, Academia Sinica, Taipei 115, Taiwan.ORCID 0000-0003-1374-0414
Hung-Wen LiuDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0001-8953-4794

Funding

Three-Membered Ring Metabolites, Inhibition &FormationR01GM040541 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI LIU, HUNG-WEN · 1989 to 2023
$7.4M
Determining the Architectures and Activities of Polyketide Synthase ModulesR01GM106112 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI KEATINGE-CLAY, ADRIAN TRISTAN · 2013 to 2025
$3.9M
NIGMS NIH HHS R01 GM040541NIGMS NIH HHS R01 GM106112
6 · The paper itself

Abstract

The catalog of enzymes known to catalyze the nucleophile-assisted formation of C-C bonds is extremely small, and there is presently no definitive example of a biological Rauhut-Currier reaction. Biosynthesis of the polyketide insecticide spinosyn A in

Indexed as

Bacterial ProteinsBiocatalysisCatalytic DomainCysteineIsomerasesMacrolidesModels, ChemicalSaccharopolysporaBacterial ProteinsCysteineIsomerasesMacrolidesspinosyn A

Identifiers

PMID34813308
PMCPMC8665079

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.