ReviewChemical reviews2022
Photochemical and Electrochemical Applications of Proton-Coupled Electron Transfer in Organic Synthesis.
Review in Chemical reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers.
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Who cites it
141 citing papers in PubMed.
- Net fluorine atom transfer from the perspective of a PCET chemist.Chemical communications (Cambridge, England) · 2026Review
- Mapping Proton-Coupled Electron Transfer With Real Space Coordinates.Angewandte Chemie (International ed. in English) · 2026Article
- Proton-gated multisite concerted proton-electron transfer-like pathway in a dual-atom framework for selective water purification.Nature communications · 2026Article
- First-Principles Insights into Proton-Coupled Electron Transfer versus Hydrogen Evolution Reaction Selectivity from a Base-Appended Cobaltocene Mediator.Inorganic chemistry · 2026Article
- Repositioning Proton and Electron Donors in a Family of Proton-Coupled Electron Transfer Mediators.Inorganic chemistry · 2026Article
- Boron Amidate as a Modular Anionic Catalyst for Sequential Electron-Donor/Hydrogen-Atom-Transfer Catalysis.Precision chemistry · 2026Article
- Programmable Control Over Radical and Non‑Radical Pathways in Fenton‑Like Catalysis via Carbon‑Encapsulated Iron Nanoreactors.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Article
- Oxidative PCET-Triggered Benzylic C─H Iminolactonization via 1,5-HAT/Cyclization Enabled by Cage-Confined Photocatalysis.Angewandte Chemie (International ed. in English) · 2026Article
- Redox-protonation landscape of indene-annulated perylenes: chemodivergent switching of multistate NIR chromophores.Chemical science · 2026Article
- Unveiling the Potential ofJournal of the American Chemical Society · 2026Article
- Redirecting radical phosphonylation via energy-transfer-enabled diradical rearrangement.Science advances · 2026Article
- Article
- Deprotonative Single-Electron Oxidation as a General and Controllably Selective Platform for Benzylic C-H Functionalization.Journal of the American Chemical Society · 2026Article
- Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- The Far Side of Carboranes: Anticancer Active Monocations and Ambiently Stable Dications.Angewandte Chemie (International ed. in English) · 2026Article
- Distance-Dependent, Rate-Accelerating and Diastereoselective Directing Effects in Decatungstate-Mediated Stereoediting Reactions.Journal of the American Chemical Society · 2026Article
- Proton-Coupled Electron and Energy Transfer in Molecular Triads.Accounts of chemical research · 2026Article
- Transformational Catalytic Innovation Supports COChemistryOpen · 2026Review
- Sustainable Oxidation of Azoles: Structure-Reactivity Controls and Reactive Species Dynamics in UV-Activated Persulfate Processes.ChemSusChem · 2026Article
81 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors.
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Abstract
We present here a review of the photochemical and electrochemical applications of multi-site proton-coupled electron transfer (MS-PCET) in organic synthesis. MS-PCETs are redox mechanisms in which both an electron and a proton are exchanged together, often in a concerted elementary step. As such, MS-PCET can function as a non-classical mechanism for homolytic bond activation, providing opportunities to generate synthetically useful free radical intermediates directly from a wide variety of common organic functional groups. We present an introduction to MS-PCET and a practitioner's guide to reaction design, with an emphasis on the unique energetic and selectivity features that are characteristic of this reaction class. We then present chapters on oxidative N-H, O-H, S-H, and C-H bond homolysis methods, for the generation of the corresponding neutral radical species. Then, chapters for reductive PCET activations involving carbonyl, imine, other X═Y π-systems, and heteroarenes, where neutral ketyl, α-amino, and heteroarene-derived radicals can be generated. Finally, we present chapters on the applications of MS-PCET in asymmetric catalysis and in materials and device applications. Within each chapter, we subdivide by the functional group undergoing homolysis, and thereafter by the type of transformation being promoted. Methods published prior to the end of December 2020 are presented.
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